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Cited by 293

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Cure of Helicobacter pylori Infection and Duration of Remission of Low-Grade Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

Neubauer, A., Thiede, C., Alpen, B., Ritter, M., Neubauer, B., Ehninger, G., Morgner, A., Bayerdorffer, E., Wundisch, T., Stolte, M.·1997·JNCI Journal of the National Cancer Institute
DOI 10.1093/jnci/89.18.1350
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Abstract

BACKGROUND: Low-grade B-cell lymphomas arising in mucosa-associated lymphoid tissue (MALT) are most frequently localized in the gastrointestinal tract. More than 90% of gastric MALT lymphomas are diagnosed in patients with chronic, Helicobacter pylori-associated gastritis. High remission rates for these lymphomas have been observed after the cure of H. pylori infection. Data are lacking, however, with regard to the duration of the remissions. To address this question of remission duration, we have followed 50 patients in whom H. pylori infections were eradicated, and we determined whether the patients in complete remission displayed evidence of residual monoclonal B cells during follow-up. METHODS: Patients were treated with amoxycillin and omeprazole for 2 weeks in an attempt to cure H. pylori infections. Follow-up included endoscopic investigations with biopsy sampling. Monoclonal B cells in biopsy specimens were detected by means of a polymerase chain reaction (PCR)-based assay. RESULTS: H. pylori infections were cured in all 50 patients. The median follow-up for the 50 patients is currently 24 months (729 days; range, 135-1411 days). Forty patients achieved complete remission of their lymphomas, but five have subsequently relapsed. The median time of continuous complete remission for the 40 patients was 15.4 months (468 days; range, 0-1198 days). Among six patients whose Iymphomas did not respond to H. pylori eradication, four revealed high-grade lymphomas upon surgery. PCR indicated the presence of monoclonal B cells during follow-up in 22 of 31 assessable patients in complete remission. CONCLUSIONS: Complete remissions of low-grade gastric MALT Iymphomas after the cure of H. pylori infection appear to be stable, although most patients display evidence of monoclonal B cells during follow-up. Whether these patients are truly cured of their Iymphomas remains to be determined.

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Metadata

Authors
Neubauer, A., Thiede, C., Alpen, B., Ritter, M., Neubauer, B., Ehninger, G., Morgner, A., Bayerdorffer, E., Wundisch, T., & Stolte, M.
Venue
JNCI Journal of the National Cancer Institute
Publisher
Oxford University Press (OUP)
Published
1997-09-17
Volume
89
Issue
18
Pages
1350-1355
ISSN
  • 0027-8874 (ISSN-L)
  • 1460-2105
DOI
10.1093/jnci/89.18.1350
OpenAlex
W2141260928
Cited by
293
References
18
FWCI
24.87
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Cure of Helicobacter pylori Infection and Duration of Remission of Low-Grade Gastric Mucosa-Associated Lymphoid Tissue Lymphoma. https://app.cochat.ai/papers/10.1093/jnci/89.18.1350
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Neubauer, A., Thiede, C., Alpen, B., Ritter, M., Neubauer, B., Ehninger, G., Morgner, A., Bayerdorffer, E., Wundisch, T., & Stolte, M. (1997). Cure of Helicobacter pylori Infection and Duration of Remission of Low-Grade Gastric Mucosa-Associated Lymphoid Tissue Lymphoma. JNCI Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/89.18.1350

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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