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Mitotic Kinase Expression and Colorectal Cancer Progression
Open accessAbstract
Loss of chromosomal integrity as well as genomic stability is considered to act as a driving force during the processes of tumorigenesis and tumor progression ( 1 - 3 ). Recently, two kinase genes involved in mitosis, the genes for aurora and IPL1-like midbody-associated protein kinase-1 ( 4 , 5 ) [AIM-1, registered in UniGene and also known as aurora1 ( 6 ) and ARK2 ( 7 )] and for serine/threonine kinase-6 [STK6, also known as BTAK/STK15 ( 8 , 9 ), Aik ( 10 ), aurora2 ( 6 ), and ARK1 ( 7 )], which are related to Ipl1 in Saccharomyces cerevisiae and aurora in Drosophila, have been found to be expressed at high levels in cancer cells ( 5,6,9 ). These genes encode serine/threonine protein kinases whose functional roles during chromosomal segregation processes in mitosis have been examined ( 4 - 10 ). In transfected human cells in vitro, the overexpression of either AIM-1 or STK6 causes chromosomal abnormalities, which are presumably attributed to a defect in the mitotic processes ( 5 , 9 ). Thus, these genes may be involved in the loss of chromosomal integrity during human cancer development via mitotic subversion.
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Cited by
Harrington, E. A., Bebbington, D., Moore, J., Rasmussen, R. K., Ajose-Adeogun, A. O., Nakayama, T., Graham, J. A., Demur, C., Hercend, T., Diu-Hercend, A., et al. (2004) · Nature Medicine · doi:10.1038/nm1003 · Cited by 965
Difference Between Left-Sided and Right-Sided Colorectal Cancer: A Focused Review of Literature
Baran, B., Mert Ozupek, N., Yerli Tetik, N., Acar, E., Bekcioglu, O., & Baskin, Y. (2018) · Gastroenterology Research · doi:10.14740/gr1062w · Cited by 553
LaBonte, M. J., Wilson, P. M., Fazzone, W., Groshen, S., Lenz, H.-J., & Ladner, R. D. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-67 · Cited by 99
Metadata
- Authors
- Katayama, H., Ota, T., Jisaki, F., Ueda, Y., Tanaka, T., Odashima, S., Suzuki, F., Terada, Y., & Tatsuka, M.
- Venue
- JNCI Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-07-07
- Volume
- 91
- Issue
- 13
- Pages
- 1160-1162
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2122230117
- Cited by
- 177
- References
- 0
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Katayama, H., Ota, T., Jisaki, F., Ueda, Y., Tanaka, T., Odashima, S., Suzuki, F., Terada, Y., & Tatsuka, M. (1999). Mitotic Kinase Expression and Colorectal Cancer Progression. JNCI Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/91.13.1160
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
