The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Colorectal Cancer Mortality: Effectiveness of Biennial Screening for Fecal Occult Blood
Abstract
BACKGROUND: In 1993, a randomized controlled trial in Minnesota showed, after 13 years of follow-up, that annual fecal occult blood testing was effective in reducing colorectal cancer mortality by at least 33%. Biennial screening (i.e., every 2 years) resulted in only a 6% mortality reduction. Two European trials (in England and in Denmark) subsequently showed statistically significant 15% and 18% mortality reductions with biennial screening. Herein, we provide updated results-through 18 years of follow-up--from the Minnesota trial that address the apparent inconsistent findings among the trials regarding biennial screening. METHODS: From 1976 through 1977, a total of 46551 study subjects, aged 50-80 years, were recruited and randomly assigned to an annual screen, a biennial screen, or a control group. A screen consisted of six guaiac-impregnated fecal occult blood tests (Hemoccult) prepared in pairs from each of three consecutive fecal samples. Participants with at least one of the six tests that were positive were invited for a diagnostic examination that included colonoscopy. All participants were followed annually to ascertain incident colorectal cancers and deaths. RESULTS: The numbers of deaths from all causes were similar among the three study groups. Cumulative 18-year colorectal cancer mortality was 33% lower in the annual group than in the control group (rate ratio, 0.67; 95% confidence interval [CI] = 0.51-0.83). The biennial group had a 21% lower colorectal cancer mortality rate than the control group (rate ratio, 0.79; 95% CI = 0.62-0.97). A marked reduction was also noted in the incidence of Dukes' stage D cancers in both screened groups in comparison with the control group. CONCLUSION: The results from this study, together with the other two published randomized trials of fecal occult blood screening, are consistent in demonstrating a substantial, statistically significant reduction in colorectal cancer mortality from biennial screening.
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Cites
Reducing Mortality from Colorectal Cancer by Screening for Fecal Occult Blood
Mandel, J. S., Bond, J. H., Church, T. R., Snover, D. C., Bradley, G. M., Schuman, L. M., & Ederer, F. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305133281901 · Cited by 3,229
Self-citationInternational Classification of Diseases
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Maximum utilization of the life table method in analyzing survival
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“Cumulative estimates of mortality from colorectal cancer at the end of each follow-up year were made with the life table technique, with deaths from other causes censored (13,14).”
MethodSelf-citationRandomised controlled trial of faecal-occult-blood screening for colorectal cancer
Hardcastle, J. D., Chamberlain, J. O., Robinson, M. H., Moss, S. M., Amar, S. S., Balfour, T. W., James, P. D., & Mangham, C. M. (1996) · The Lancet · doi:10.1016/s0140-6736(96)03386-7 · Cited by 2,793
Randomised study of screening for colorectal cancer with faecal-occult-blood test
Kronborg, O., Fenger, C., Olsen, J., Jørgensen, O. D., & Søndergaard, O. (1996) · The Lancet · doi:10.1016/s0140-6736(96)03430-7 · Cited by 2,501
The classification of cancer of the rectum
Dukes, C. E. (1932) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700350303 · Cited by 1,505
CENTENO, A. M. (1951) · PubMed · Cited by 272
LANG, C. A. (1994) · JAMA · doi:10.1001/jama.271.13.1011 · Cited by 136
Mandel, J. S., Bond, J. H., Bradley, M., Snover, D. C., Church, T. R., Williams, S. E., Watt, G. D., Schuman, L. M., Ederer, F., & Gilbertsen, V. A. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90629-x · Cited by 127
Self-citationFecal occult blood screening for colorectal cancer
Dam, J. V. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.155.22.2389 · Cited by 53
Cited by
WINAWER, S. (2003) · Gastroenterology · doi:10.1053/gast.2003.50044 · Cited by 2,143
Colorectal-Cancer Incidence and Mortality with Screening Flexible Sigmoidoscopy
Schoen, R. E., Pinsky, P. F., Weissfeld, J. L., Yokochi, L. A., Church, T., Laiyemo, A. O., Bresalier, R., Andriole, G. L., Buys, S. S., Crawford, E. D., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1114635 · Cited by 1,021
Self-citationPignone, M., Rich, M., Teutsch, S. M., Berg, A. O., & Lohr, K. N. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-2-200207160-00015 · Cited by 741
The human gut microbiome as a screening tool for colorectal cancer
Zackular, J. P., Rogers, M. A. M., Ruffin, M. T., & Schloss, P. D. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0129 · Cited by 551
Patterns and predictors of colorectal cancer test use in the adult U.S. population
Seeff, L. C., Nadel, M. R., Klabunde, C. N., Thompson, T., Shapiro, J. A., Vernon, S. W., & Coates, R. J. (2004) · Cancer · doi:10.1002/cncr.20276 · Cited by 538
Metadata
- Authors
- Mandel, J. S., Church, T. R., Ederer, F., & Bond, J. H.
- Venue
- JNCI Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-03-03
- Volume
- 91
- Issue
- 5
- Pages
- 434-437
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2134997723
- Cited by
- 788
- References
- 13
- FWCI
- 14.55
- Type
- journal article
- Language
- en
- Open access
- closed
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