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Cited by 189Growth Hormone and Insulin-like Growth FactorsNutritional Studies and DietColorectal Cancer Screening and Detection

Milk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men

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Ma, J., Giovannucci, E., Pollak, M., Chan, J. M., Gaziano, J. M., Willett, W., Stampfer, M. J.·2001·JNCI Journal of the National Cancer Institute
DOI 10.1093/jnci/93.17.1330
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Abstract

Background Milk and dietary calcium may have antiproliferative effects against colorectal cancer, but milk intake also raises serum levels of insulin-like growth factor-I (IGF-I). A high ratio of IGF-I to IGF-binding protein-3 (IGFBP-3) has been linked to an increased risk of colorectal cancer. Methods In a case-control study nested in the Physicians' Health Study, plasma samples were collected from the period 1982 through 1983 from 14 916 men, aged 40-84 years, who also answered dietary questionnaires. Circulating levels of IGF-I and IGFBP-3 were assayed among 193 men who developed colorectal cancer during 13 years of follow-up and 318 age- and smoking-matched cancer-free control men. Conditional logistic regression was used to assess relative risks (RRs) of colorectal cancer for tertiles of IGF-I/IGFBP-3 and dietary factors. Statistical tests were two-sided. Results Overall, there was a moderate but statistically nonsignificant inverse association between intake of low-fat milk or calcium from dairy food and colorectal cancer risk. Intake of dairy food (especially low-fat milk) was also positively and moderately associated with plasma levels of IGF-I, IGFBP-3, and IGF-I/IGFBP-3 among control men. We observed a statistically significant interaction between low-fat milk intake and IGF-I/IGFBP-3 in association with risk of colorectal cancer (P(interaction) =.03). Nondrinkers with IGF-I/IGFBP-3 in the highest tertile had a threefold higher risk than nondrinkers with IGF-I/IGFBP…

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  • A majority of the negative studies, including 1 notable study that reported that increased milk consumption decreased the risk of acne scarring, were conducted in countries outside the United States and Europe.

    “Importantly, a majority of the negative studies, including 1 notable study that reported that increased milk consumption decreased the risk of acne scarring,53,54 were conducted in countries outside the United States and Europe.”

    From Diet and acne: A systematic review (2022) · cites this paper as [54]

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Authors
Ma, J., Giovannucci, E., Pollak, M., Chan, J. M., Gaziano, J. M., Willett, W., & Stampfer, M. J.
Affiliations
Brigham and Women's Hospital (US)
ORCID
Venue
JNCI Journal of the National Cancer Institute
Publisher
Oxford University Press (OUP)
Published
2001-09-05
Volume
93
Issue
17
Pages
1330-1336
ISSN
  • 0027-8874 (ISSN-L)
  • 1460-2105
DOI
10.1093/jnci/93.17.1330
OpenAlex
W2163019061
Cited by
189
References
0
Citations by year
2026: 3 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 9 · 2019: 8 · 2018: 7 · 2017: 10 · 2016: 2 · 2015: 6 · 2014: 7 · 2013: 7 · 2012: 4
FWCI
7.99
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • JNCI Journal of the National Cancer Institute (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders
National Cancer Institute (R01CA040360, R01CA042182, CA 42182, CA78293, CA 40360, R29CA078293)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
Keywords
colorectal cancer, milk consumption, low-fat milk, dairy products, insulin-like growth factor I, IGF binding protein-3, IGF-I/IGFBP-3 ratio, dietary calcium, cancer risk, men, Physicians' Health Study, non-drinkers, antiproliferative activity, plasma biomarkers
MeSH terms
Adult, Aged, Aged, 80 and over, Animals, Calcium, Dietary, Dairy Products, Feeding Behavior, Fishes, Humans, Insulin-Like Growth Factor I, Male, Meat, Middle Aged, Milk, Poultry, Risk, Colorectal Neoplasms, Logistic Models, Case-Control Studies, Insulin-Like Growth Factor Binding Protein 3

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