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Completion of Therapy by Medicare Patients With Stage III Colon Cancer
Open accessAbstract
BACKGROUND: Certain factors, such as race or age, are known to be associated with variation in initiation of adjuvant chemotherapy for stage III colon cancer, but little is known about what factors are associated with completion of adjuvant therapy. To determine whether predictors of initiation also predict completion, we analyzed Surveillance, Epidemiology, and End Results (SEER) program data linked to Medicare claims. We investigated mortality as a means to testing the validity of the completion measure that we created. METHODS: We studied 3193 stage III colon cancer patients whose diagnosis was recorded in 1992-1996 SEER program data linked to 1991-1998 Medicare claims and who initiated adjuvant chemotherapy after colon cancer resection. We defined a measure of adjuvant chemotherapy completion as one chemotherapy administration claim in a month. We tested the validity of the created measure and its relation to 3-year cancer mortality adjusted for demographic, clinical, and environmental variables. We explored the association of patient characteristics and treating physician characteristics with chemotherapy completion by use of multivariable logistic regression modeling. RESULTS: Of the 3193 patients, 2497 (78.2%) completed the course. Risk of cancer-related mortality was statistically significantly lower among those completing chemotherapy (relative risk = 0.79, 95% confidence interval = 0.69 to 0.89) than those with no adjuvant therapy. Patients who were female, widowed, increasingly elderly, rehospitalized, and living in certain regions were less likely to complete adjuvant chemotherapy than other patients. Race and other clinical, environmental, and physician characteristics were not associated with completion of therapy. CONCLUSIONS: Factors associated with incomplete adjuvant chemotherapy may represent physical frailty, treatment complications, and lack of social and psychological support. Interventions to mitigate these influences are a logical next step toward increasing chemotherapy completion rates.
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“especially lung and gastrointestinal cancers which have a poor prognosis and high symptom profile (12, 13).”
From Coping in Patients With Incurable Lung and Gastrointestinal Cancers: A Validation Study of the Brief COPE (2017) · cites this paper as [13]
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Cites
Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90171-8 · Cited by 49,742
(2016) · Springer eBooks · doi:10.1007/978-3-319-40618-3 · Cited by 17,300
(2002) · Springer eBooks · doi:10.1007/978-1-4757-3656-4 · Cited by 6,375
Zhang, J., & Yu, K. F. (1998) · JAMA · doi:10.1001/jama.280.19.1690 · Cited by 4,138
Levamisole and Fluorouracil for Adjuvant Therapy of Resected Colon Carcinoma
Moertel, C. G., Fleming, T. R., Macdonald, J. S., Haller, D. G., Laurie, J. A., Goodman, P. J., Ungerleider, J. S., Emerson, W. A., Tormey, D. C., Glick, J. H., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199002083220602 · Cited by 2,261
Warren, J. L., Klabunde, C. N., Schrag, D., Bach, P. B., & Riley, G. F. (2002) · PubMed · doi:10.1097/01.mlr.0000020942.47004.03 · Cited by 1,719
Romano, P. S., Roos, L. L., & Jollis, J. G. (1993) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(93)90103-8 · Cited by 1,717
Adjuvant Therapy for Patients With Colon and Rectal Cancer
(1990) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1990.03450110090034 · Cited by 1,086
A Pooled Analysis of Adjuvant Chemotherapy for Resected Colon Cancer in Elderly Patients
Sargent, D. J., Goldberg, R. M., Jacobson, S. D., Macdonald, J. S., Labianca, R., Haller, D. G., Shepherd, L. E., Seitz, J. F., & Francini, G. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010957 · Cited by 981
Moertel, C. G., Fleming, T. R., Macdonald, J. S., Haller, D. G., Laurie, J. A., Tangen, C. M., Ungerleider, J. S., Emerson, W. A., Tormey, D. C., Glick, J. H., et al. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-122-5-199503010-00001 · Cited by 924
Research works printed but not linked: 2
- Wolmark N, Rockette H, Mamounas EP, Jones J, Petrelli N, Atkins J. The relative efficacy of 5-FU+leucovorin (FU-LV), 5-FU+levamisole (FU-LEV) and 5-FU+leucovorin+levamisole (FU-LV-LEV) in patients with Ducke's B and C carcinoma of the colon: first report of NSABP C-04 Proc ASCO 1996 ;15:205.
- Bower M, Asbury R, Kramer Z, Pandya K, Bennett JM. Adjuvant chemotherapy for colorectal cancer in the elderly: population-based experience. Proc ASCO1993 ; 12 : 195 (Abs #570).
Cited by
Sorted by citations
Items 101–150 of 150
Chun, K. H., Bae, B. N., An, H., Jeong, H., Cho, H., Gwak, G., Yang, K., Kim, K. H., Kim, H. J., & Kim, Y. D. (2014) · Annals of Coloproctology · doi:10.3393/ac.2014.30.6.274 · Cited by 9
Personalized Adjuvant Treatment of Colon Cancer
Taghizadeh, H., & Prager, G. W. (2020) · Visceral Medicine · doi:10.1159/000508175 · Cited by 10
Gaitonde, S. G., Nissan, A., Protić, M., Stojadinovic, A., Wainberg, Z. A., Chen, D. C., & Bilchik, A. J. (2017) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2017.02.019 · Cited by 9
Consensus on the medical treatment of colon cancer
Kornek, G. V., Scheithauer, W., Anghel, R. M., Bodoky, G., Ciardiello, F., Ciuleanu, T.-E., Glynne‐Jones, R., Gruenberger, T., Koza, I., Ocvirk, J., et al. (2008) · memo - Magazine of European Medical Oncology · doi:10.1007/s12254-008-0036-2 · Cited by 9
Yu, X., & McBean, A. M. (2010) · BMC Health Services Research · doi:10.1186/1472-6963-10-98 · Cited by 8
T4N0 colon cancers should be treated like T3N1 disease
Chan, D. K. H., Lim, T., & Tan, K. (2018) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo.2018.09.17 · Cited by 7
Scheepers, E. R. M., Schiphorst, A. H. W., van Huis‐Tanja, L. H., Emmelot‐Vonk, M. H., & Hamaker, M. E. (2021) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2021.01.029 · Cited by 7
Re: Completion of Therapy by Medicare Patients With Stage III Colon Cancer
Gibbs, P., McLaughlin, S., Skinner, I., Jones, I. T., Hayes, I., Chapman, M., Johns, J., Lim, L., & Faragher, I. G. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj416 · Cited by 6
Adjuvant Treatment in Colorectal Cancer
Ivanov, K., Kolev, N. Y., Shterev, I., Tonev, A. Y., Ignatov, V., Bojkov, V., & Kirilov, T. (2014) · InTech eBooks · doi:10.5772/56914 · Cited by 5
Adjuvant chemotherapy for stage C colonic cancer in a multidisciplinary setting
Chapuis, P. H., Bokey, E. L., Clarke, S. J., Beale, P. J., & Dent, O. F. (2009) · ANZ Journal of Surgery · doi:10.1111/j.1445-2197.2009.05052.x · Cited by 5
Knotts, C. M., Horn, A. L. V., Orminski, K., Thompson, S., Minor, J., Elmore, M., & Richmond, B. K. (2022) · The American Surgeon · doi:10.1177/00031348211054708 · Cited by 5
Do Elderly Cancer Patients Achieve an Adequate Dose Intensity in Common Clinical Practice?
Luciani, A., Marussi, D., Ascione, G., Caldiera, S., Ferrari, D., Oldani, S., Uziel, L. D., Zonato, S., & Foa, P. (2006) · Oncology · doi:10.1159/000108386 · Cited by 5
Park, Y. Y., Lee, K. Y., Kim, N. K., Lee, S. B., Kim, G. R., Min, B. S., & Oh, S. T. (2019) · Annals of Coloproctology · doi:10.3393/ac.2019.03.10 · Cited by 4
Clin‐ STAR Corner: Practice Changing Advances at the Interface of Oncology and Geriatrics
Phillips, T., Ji, J., Katheria, V., & Dale, W. (2024) · Journal of the American Geriatrics Society · doi:10.1111/jgs.19361 · Cited by 3
Ahmed, F. A., Wu, V. S., Kakish, H. H., Rothermel, L. D., Stein, S. L., Steinhagen, E. F., & Hoehn, R. S. (2023) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-023-05748-z · Cited by 3
Alnajjar, S., Shoucair, S., Almanzar, A., Zheng, K., Lisle, D. M., & Gupta, V. K. (2024) · The American Surgeon · doi:10.1177/00031348241248689 · Cited by 3
Geva, R., Sarid, N., & Shacham‐Shmueli, E. (2015) · Journal of Clinical Gerontology and Geriatrics · doi:10.1016/j.jcgg.2015.02.006 · Cited by 3
Copur, M. S. (2009) · Clinical Colorectal Cancer · doi:10.3816/ccc.2009.n.031 · Cited by 3
Colon Cancer in Elderly Patients: What is the Best Treatment?
Pasetto, L. M., Jirillo, A., Lonardi, S., Falci, C., & Monfardini, S. (2008) · Aging Health · doi:10.2217/1745509x.4.3.279 · Cited by 2
Lin, D., Goldberg, J. D., Hochman, T., Levinson, B. A., Khan, M. R., Newman, E., Leichman, L. P., & Gold, H. T. (2017) · Cancer Causes & Control · doi:10.1007/s10552-017-0996-6 · Cited by 2
Simon, H. L., de Paula, T. R., Spigel, Z. A., & Keller, D. S. (2022) · Diseases of the Colon & Rectum · doi:10.1097/dcr.0000000000002656 · Cited by 2
Completion Rates of Adjuvant Chemotherapy for Colon Cancer: A Historical Perspective
Grann, V. R., & Muggia, F. M. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj184 · Cited by 2
Hoffmann, M., Ogbonnaya, L., Benecke, C., Braun, R., Zimmermann, M., Schloericke, E., & Keck, T. (2018) · International Journal of Surgery Open · doi:10.1016/j.ijso.2018.09.001 · Cited by 1
Bai, F., Hu, T., Li, B., Li, J., Zhang, L., Yao, X., Yang, F., Yang, H., Xu, L., & Zhao, L. (2026) · Strahlentherapie und Onkologie · doi:10.1007/s00066-026-02535-y · Cited by 1
Hsieh, C.-I., Kuo, R. N.-C., Liang, C.-C., Tsai, H., & Chung, K. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-021341 · Cited by 1
Thanh, L. H., Manh, K. N., Thi, M. N., Trung, A. N. T., Trung, K. N., Viet, T. L., & Huy, N. V. (2023) · Cureus · doi:10.7759/cureus.43243 · Cited by 1
Alyabsi, M. S., Alqarni, A. H., Almutairi, A. F., Alselaim, N. A., Algarni, M., & Alshammari, K. M. (2023) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_261_23 · Cited by 1
Imaoka, K., Shimomura, M., Okuda, H., Yano, T., Akabane, S., Ohira, M., Imaoka, Y., Mochizuki, T., Hattori, M., & Ohdan, H. (2024) · Cureus · doi:10.7759/cureus.71288 · Cited by 1
Is Colon Cancer Survival Influenced by Tumor Location?
Meyers, B. M., Dhesy‐Thind, S., & Zbuk, K. M. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.41.3419 · Cited by 1
Lillini, R. (2016) · BOA (University of Milano-Bicocca) · Cited by 1
Michnevich, T. L., Pan, Y., Hendi, A., Oechsle, K., Stein, A., & Nestoriuc, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-926779/v1 · Cited by 1
Management of colon and rectal cancer in older adults
Mohile, S. G., Kaur, H. P., & Goldberg, R. M. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511763182.011
Kim, M., & Kang, W. K. (2014) · Annals of Coloproctology · doi:10.3393/ac.2014.30.6.250
La chimiothérapie dans les cancers colorectaux chez les sujets âgés
Mitry, E. (2008) · ONCOLOGIE · doi:10.1007/s10269-008-0844-0
Comparative Effectiveness of Adjuvant Chemotherapy in Elderly Colon Cancer Patients
Satram‐Hoang, S., Lee, L., Yu, S., Momin, F., Guduru, S. R., Reyes, C. M., & Mckenna, E. F. (2013) · Cancer and Clinical Oncology · doi:10.5539/cco.v2n1p115
Adjuvant chemotherapy outcomes in patients over 65 years with early stage colorectal carcinoma.
Civelek, B., Aksoy, S., Şendur, M. A. N., Yazıcı, O., Kanmaz, H., Köş, F. T., Yildirim, N., Uncu, D., & Zengin, N. (2014) · PubMed
Lund, J. L. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/g32t-zs66
Completion of Therapy by Medicare Patients With Stage III Colon Cancer
Loehrer, P. J. (2007) · Yearbook of Oncology · doi:10.1016/s1040-1741(08)70452-4
Loehrer, P. J. (2008) · Yearbook of Oncology · doi:10.1016/s1040-1741(08)79026-2
Behrens, R. J., Soori, G. S., Dakhil, S. R., Mowat, R. B., Kuebler, J. P., Kim, G. P., Mazurczak, M. A., & Hornberger, J. C. (2014)
Hemoglobinopathies and Adverse Cancer-Related Outcomes
Hoag, J. R. (2017) · OpenCommons at University of Connecticut (University of Connecticut)
Itkin, B. (2018) · Open Access Journal of Cancer & Oncology · doi:10.23880/oajco-16000134
Hashimoto, Y., Hayashi, A., Tonegawa, T., Teng, L., & Igarashi, A. (2022) · Journal of Market Access & Health Policy · doi:10.1080/20016689.2022.2057651
Frailty and quality of life in older adults with cancer
Scheepers, E. R. M. (2022) · Utrecht University Repository (Utrecht University) · doi:10.33540/495
Imaoka, K., Shimomura, M., Okuda, H., Yano, T., Akabane, S., Ohira, M., Imaoka, Y., Ono, K., Mochizuki, T., Matsubara, K., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4356279/v1
Adjuvant Chemotherapy for Senior Patients After Resection of Colon Cancer
Ong, S. Y.-K. (2012) · Springer eBooks · doi:10.1007/978-3-642-29883-7_15
Michnevich, T. L., Pan, Y., Hendi, A., Oechsle, K., Stein, A., & Nestoriuc, Y. (2022) · Figshare · doi:10.6084/m9.figshare.21192169
Marqués, A., Henriques, J., Vernerey, D., Parc, Y. R., Lefèvre, J. H., Voron, T., Cohen, R., André, T., & Samaille, T. (2026) · JCO Oncology Practice · doi:10.1200/op-25-01035
Metadata
- Authors
- Dobie, S. A., Baldwin, L.-M., Dominitz, J. A., Matthews, B., Billingsley, K., & Barlow, W.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Dobie, Sharon A.
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-05-03
- Volume
- 98
- Issue
- 9
- Pages
- 610-619
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- PMC
- PMC3124351
- OpenAlex
- W2108822192
- Cited by
- 150
- References
- 53
- Citations by year
- 2026: 2 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 9 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 8 · 2015: 8 · 2014: 13 · 2013: 11 · 2012: 11
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JNCI Journal of the National Cancer Institute (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA089544)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Keywords
- stage III colon cancer, adjuvant chemotherapy, chemotherapy completion, Medicare beneficiaries, cancer mortality, predictors of treatment completion, patient characteristics, physician characteristics, SEER, Medicare claims data
- MeSH terms
- Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Colonic Neoplasms, Female, Medicare, Humans, Male, Neoplasm Staging, Patient Compliance, Predictive Value of Tests, Risk Factors, Social Support, United States, Reproducibility of Results, Logistic Models, Frail Elderly, Chemotherapy, Adjuvant, SEER Program
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