The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Alcohol Drinking in Never Users of Tobacco, Cigarette Smoking in Never Drinkers, and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium
Open accessAbstract
BACKGROUND: At least 75% of head and neck cancers are attributable to a combination of cigarette smoking and alcohol drinking. A precise understanding of the independent association of each of these factors in the absence of the other with the risk of head and neck cancer is needed to elucidate mechanisms of head and neck carcinogenesis and to assess the efficacy of interventions aimed at controlling either risk factor. METHODS: We examined the extent to which head and neck cancer is associated with cigarette smoking among never drinkers and with alcohol drinking among never users of tobacco. We pooled individual-level data from 15 case-control studies that included 10,244 head and neck cancer case subjects and 15,227 control subjects, of whom 1072 case subjects and 5775 control subjects were never users of tobacco and 1598 case subjects and 4051 control subjects were never drinkers of alcohol. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models. All statistical tests were two-sided. RESULTS: Among never drinkers, cigarette smoking was associated with an increased risk of head and neck cancer (OR for ever versus never smoking = 2.13, 95% CI = 1.52 to 2.98), and there were clear dose-response relationships for the frequency, duration, and number of pack-years of cigarette smoking. Approximately 24% (95% CI = 16% to 31%) of head and neck cancer cases among nondrinkers in this study would have been prevented if these individuals had not smoked cigarettes. Among never users of tobacco, alcohol consumption was associated with an increased risk of head and neck cancer only when alcohol was consumed at high frequency (OR for three or more drinks per day versus never drinking = 2.04, 95% CI = 1.29 to 3.21). The association with high-frequency alcohol intake was limited to cancers of the oropharynx/hypopharynx and larynx. CONCLUSIONS: Our results represent the most precise estimates available of the independent association of each of the two main risk factors of head and neck cancer, and they exemplify the strengths of large-scale consortia in cancer epidemiology.
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“We assumed that the education data were missing at random, i.e., whether or not education level was missing did not depend on any other unobserved or missing values ( 35 ).”
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Cited by
Hashibe, M., Brennan, P., Chuang, S.-C., Boccia, S., Castellsague, X., Chen, C., Curado, M. P., Dal Maso, L., Daudt, A. W., Fabianova, E., et al. (2009) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0347 · Cited by 1,256
Self-citationLight alcohol drinking and cancer: a meta-analysis
Bagnardi, V., Rota, M., Botteri, E., Tramacere, I., Islami, F., Fedirko, V., Scotti, L., Jenab, M., Turati, F., Pasquali, E., et al. (2013) · Annals of Oncology · doi:10.1093/annonc/mds337 · Cited by 424
Self-citationLifestyle risk factors for oral cancer
Petti, S. (2009) · Oral Oncology · doi:10.1016/j.oraloncology.2008.05.018 · Cited by 417
Oral health risks of tobacco use and effects of cessation
Warnakulasuriya, S., Dietrich, T., Bornstein, M. M., Peidró, E. C., Preshaw, P. M., Walter, C., Wennström, J. L., & Bergström, J. (2010) · International Dental Journal · doi:10.1016/s0020-6539(20)34036-3 · Cited by 393
Molinolo, A. A., Hewitt, S. M., Amornphimoltham, P., Keelawat, S., Rangdaeng, S., Meneses García, A., Raimondi, A. R., Jufe, R., Itoiz, M., Gao, Y., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1041 · Cited by 243
Metadata
- Authors
- Hashibe, M., Brennan, P., Benhamou, S., Castellsague, X., Chen, C., Curado, M. P., Maso, L. D., Daudt, A. W., Fabianova, E., Wunsch-Filho, V., Franceschi, S., Hayes, R. B., Herrero, R., Koifman, S., La Vecchia, C., Lazarus, P., Levi, F., Mates, D., Matos, E., Menezes, A., Muscat, J., Eluf-Neto, J., Olshan, A. F., Rudnai, P., Schwartz, S. M., Smith, E., Sturgis, E. M., Szeszenia-Dabrowska, N., Talamini, R., Wei, Q., Winn, D. M., Zaridze, D., Zatonski, W., Zhang, Z.-F., Berthiller, J., & Boffetta, P.
- Venue
- JNCI Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-05-15
- Volume
- 99
- Issue
- 10
- Pages
- 777-789
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2096995751
- Cited by
- 1,098
- References
- 3
- FWCI
- 40.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Alcohol Drinking in Never Users of Tobacco, Cigarette Smoking in Never Drinkers, and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium. https://app.cochat.ai/papers/10.1093/jnci/djk179
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- Hashibe, M., Brennan, P., Benhamou, S., Castellsague, X., Chen, C., Curado, M. P., Maso, L. D., Daudt, A. W., Fabianova, E., Wunsch-Filho, V., Franceschi, S., Hayes, R. B., Herrero, R., Koifman, S., La Vecchia, C., Lazarus, P., Levi, F., Mates, D., Matos, E., . . . Boffetta, P. (2007). Alcohol Drinking in Never Users of Tobacco, Cigarette Smoking in Never Drinkers, and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium. JNCI Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/djk179
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
