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Familial Aggregation of Common Sequence Variants on 15q24-25.1 in Lung Cancer
Open accessAbstract
Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We conducted a genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, in which we used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects. We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted.
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“The replicated nicotine dependence loci tagged by rs16969968 (96,100–102) and rs578776 (101,103) have also been reported to influence lung cancer risk in several genome-wide association studies.”
From Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery (2009) · cites this paper as [103]
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“The replicated nicotine dependence loci tagged by rs16969968 (96,100–102) and rs578776 (101,103) have also been reported to influence lung cancer risk in several genome-wide association studies.”
From Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery (2009) · cites this paper as [102]
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Metadata
- Authors
- Liu, P., Vikis, H. G., Wang, D., Lu, Y., Wang, Y., Schwartz, A. G., Pinney, S. M., Yang, P., de Andrade, M., Petersen, G. M., Wiest, J. S., Fain, P. R., Gazdar, A., Gaba, C., Rothschild, H., Mandal, D., Coons, T., Lee, J., Kupert, E., Seminara, D., Minna, J., Bailey-Wilson, J. E., Wu, X., Spitz, M. R., Eisen, T., Houlston, R. S., Amos, C. I., Anderson, M. W., & You, M.
- Affiliations
- Washington University in St. Louis (US)
- Institute of Cancer Research (GB)
- ORCID
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-09
- Volume
- 100
- Issue
- 18
- Pages
- 1326-1330
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- PMC
- PMC2538550
- OpenAlex
- W2168393969
- Cited by
- 154
- References
- 21
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 6 · 2018: 7 · 2017: 7 · 2016: 8 · 2015: 13 · 2014: 11 · 2013: 6 · 2012: 12
- FWCI
- 11.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JNCI Journal of the National Cancer Institute (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institutes of Health (n01hg065404-006, n01pc35145-19-0-7)
- National Human Genome Research Institute (N01HG65404)
- National Cancer Institute (R01CA127219, R01CA80127, R01CA093643, P30CA 22453, R01 CA 55769, (P50-CA70907, R01CA099187, R01CA063700, R01CA080127, U01CA076293, R01CA133996, U01CA76293, N01 PC 35145, R01CA055769, R01CA099147, R01CA058554, P50CA070907, R01CA63700, R01CA121197, P30CA022453)
- National Institute of Environmental Health Sciences (R01ES012063, P30ES006096, R01ES013340, P30 ES-06096)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Keywords
- lung cancer, familial aggregation, single nucleotide polymorphisms, genetic susceptibility, rs1051730, CHRNA3, CHRNA5, CHRNB4, PSMA4, family history of cancer
- MeSH terms
- Chromosomes, Human, Pair 15, DNA, Neoplasm, Genotype, Humans, Lung Neoplasms, Research Design, Smoking, Confounding Factors, Epidemiologic, Case-Control Studies, Sequence Analysis, DNA, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide
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