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International Psychometric Validation of an EORTC Quality of Life Module Measuring Cancer Related Fatigue (EORTC QLQ-FA12)
Open accessAbstract
Background: The European Organisation for Research and Treatment of Cancer (EORTC) Group has developed a new multidimensional instrument measuring cancer-related fatigue to be used in conjunction with the quality of life core questionnaire (EORTC QLQ-C30). The module EORTC QLQ-FA13 assesses physical, cognitive, and emotional aspects of cancer-related fatigue. Methods: The methodology follows the EORTC guidelines for phase IV validation of modules. This paper focuses on the results of the psychometric validation of the factorial structure of the module. For validation and cross-validation confirmatory factor analysis (maximum likelihood estimation), intraclass correlation and Cronbach alpha for internal consistency were employed. The study involved an international multicenter collaboration of 11 European and non-European countries. Results: A total of 946 patients with various tumor diagnoses were enrolled. Based on the confirmatory factor analysis, we could approve the three-dimensional structure of the module. Removing one item and reassigning the factorial mapping of another item resulted in the EORTC QLQ-FA12. For the revised scale, we found evidence supporting good local (indicator reliability ≥ 0.60, factor reliability ≥ 0.82) and global model fit (GFI t1|t2 = 0.965/0.957, CFI t1|t2 = 0.976/0.972, RMSEA t1|t2 = 0.060/0.069) for both measurement points. For each scale, test-retest reliability proved to be very good (intraclass correlation: R t1-t2 = 0.905-0.921) and internal consistency proved to be good to high (Cronbach alpha = .79-.90). Conclusion: Based on the former phase III module, the multidimensional structure was revised as a phase IV module (EORTC FA12) with an improved scale structure. For a comprehensive validation of the EORTC FA12, further aspects of convergent and divergent validity as well as sensitivity to change should be determined.
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Sorted by citations
Cancer-related fatigue: ESMO Clinical Practice Guidelines for diagnosis and treatment
Fabi, A., Bhargava, R., Fatigoni, S., Guglielmo, M., Horneber, M., Roila, F., Weis, J., Jordan, K., & Ripamonti, C. I. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2020.02.016 · Cited by 583
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“Fatigue often becomes chronic, extending for years into the cancer survivorship period (Daniels et al., 2014; Jones et al., 2016; Weis et al., 2017).”
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MethodVaz-Luís, I., Cottu, P. H., Mesleard, C., Martin, A. L., Dumas, A., Dauchy, S., Trédan, O., Levy, C., Adnet, J., Tsangaris, M. R., et al. (2019) · ESMO Open · doi:10.1136/esmoopen-2019-000562 · Cited by 104
Metadata
- Authors
- Weis, J., Tomaszewski, K. A., Hammerlid, E., Ignacio Arraras, J., Conroy, T., Lanceley, A., Schmidt, H., Wirtz, M., Singer, S., Pinto, M., Alm El-Din, M., Compter, I., Holzner, B., Hofmeister, D., Chie, W.-C., Czeladzki, M., Harle, A., Jones, L., Ritter, S., Flechtner, H.-H., Bottomley, A., & on Behalf of the EORTC Quality of Life Group
- Affiliations
- Jagiellonian University (PL)
- Affiliations of authors: Tumor Biology Centre, University Clinic Centre, Freiburg, Germany (JW); Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland (KAT); Department of Otolaryngology Head and Neck Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden (EH); Oncology Departments, Complejo Hospitalario de Navarra, Pamplona, Spain (JIA); Department of Medical Oncology, Lorraine Cancer Insti
- ORCID
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-02-07
- Volume
- 109
- Issue
- 5
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2606004101
- Cited by
- 182
- References
- 16
- Citations by year
- 2026: 15 · 2025: 25 · 2024: 24 · 2023: 26 · 2022: 29 · 2021: 15 · 2020: 15 · 2019: 13 · 2018: 12 · 2017: 7
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JNCI Journal of the National Cancer Institute (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion, cc-by-nc-nd)
- Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
- UCL Discovery (University College London) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- European Organisation for Research and Treatment of Cancer Quality of Life Group (v1 04/09)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Decision Sciences › Management Science and Operations Research › Psychometric Methodologies and Testing
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Keywords
- cancer-related fatigue, EORTC QLQ-C30, quality of life, psychometric validation, factor structure, confirmatory factor analysis, test-retest reliability, internal consistency, scale revision, international multicenter study
- MeSH terms
- Adult, Aged, Aged, 80 and over, Egypt, Emotions, Europe, Factor Analysis, Statistical, Fatigue, Mental Fatigue, Female, Humans, Male, Middle Aged, Neoplasms, Palliative Care, Psychometrics, Quality of Life, Surveys and Questionnaires, Taiwan, Reproducibility of Results, Survivors, Internationality, Young Adult
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