The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Neuronal Oxidative Stress Precedes Amyloid-β Deposition in Down Syndrome
Abstract
The predictable chronological sequence of pathological events in Down syndrome (DS) provides the opportunity to rigorously investigate the relationship between oxidative stress and amyloid-β (Aβ) deposition. In this study, we report a marked accumulation of oxidized nucleic acid, 8-hydroxyguanosine (8OHG), and oxidized protein, nitrotyrosine, in the cytoplasm of cerebral neurons in DS with the levels of nucleic acid and protein oxidation paralleling each other. Relative density measurements of neuronal 8OHG immunoreactivity showed that there was a significant increase (p < 0.02) in DS (n = 22, ages 0.3–65 yr) compared with age-matched controls (n = 10, ages 0.3–64 yr). As a function of age, 8OHG immunoreactivity increased significantly in the teens and twenties (p < 0.04), while Aβ burden only increased after age 30 (p < 0.0001). In 9 cases of DS bearing Aβ deposition, the extent of deposits of Aβ ending at amino acid 42 (Aβ42) was actually associated with a decrease in relative 8OHG (r = −0.79, p < 0.015) while Aβ40 was not. These findings suggest that in brains of patients with DS, increased levels of oxidative damage occur prior to the onset of Aβ deposition.
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Cites
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Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides
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Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro
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“These results correspond with previous reports showing that the Ab species initially deposited as senile plaques in the DS brain is predominantly Ab42 with Ab40 only appearing a decade later (15, 16).”
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Cited by
Oxidative Damage Is the Earliest Event in Alzheimer Disease
Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.759 · Cited by 1,885
Self-citationThe metallobiology of Alzheimer's disease
Bush, A. I. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00067-5 · Cited by 1,315
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de la Torre, J. C. (2002) · Stroke · doi:10.1161/01.str.0000014421.15948.67 · Cited by 853
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Involvement of oxidative stress in Alzheimer disease
Nunomura, A., Castellani, R. J., Zhu, X., Moreira, P. I., Perry, G., & Smith, M. A. (2006) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/01.jnen.0000228136.58062.bf · Cited by 611
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Metadata
- Authors
- Nunomura, A., Perry, G., Pappolla, M. A., Friedland, R. P., Hirai, K., Chiba, S., & Smith, M. A.
- Venue
- Journal of Neuropathology & Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-11-01
- Volume
- 59
- Issue
- 11
- Pages
- 1011-1017
- ISSN
- 0022-3069 (ISSN-L)
- 1554-6578
- OpenAlex
- W1222036190
- Cited by
- 320
- References
- 6
- FWCI
- 21.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nunomura, A., Perry, G., Pappolla, M. A., Friedland, R. P., Hirai, K., Chiba, S., & Smith, M. A. (2000). Neuronal Oxidative Stress Precedes Amyloid-β Deposition in Down Syndrome. Journal of Neuropathology & Experimental Neurology. https://doi.org/10.1093/jnen/59.11.1011
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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