Dendritic cells in multiple sclerosis lesions: maturation stage, myelin uptake, and interaction with proliferating T cells

Serafini, Barbara; Rosicarelli, Barbara; Magliozzi, Roberta; Stigliano, Egidio; Capello, Elisabetta; Mancardi, Gian Luigi; Aloisi, Francesca

doi:10.1093/jnen/65.2.124

Dendritic cells in multiple sclerosis lesions: maturation stage, myelin uptake, and interaction with proliferating T cells

In multiple sclerosis (MS), dendritic cells (DCs) recruited to the central nervous system (CNS) are thought to be involved in the regulation of autoimmune responses directed against myelin antigens. To better understand the role of DCs in CNS inflammation, we performed a detailed immunohistochemi…