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Functional changes in the aging kidney
Abstract
The aging process results in remarkable changes in the kidney. These changes are both anatomical and functional and have been considered the cause of the increased propensity of the elderly to acute or chronic renal failure. However, the majority of the early studies on aging enrolled institutionalized elderly patients with several comorbidities such as hypertension and heart disease which could by themselves induce renal alterations. Recently the selection of subjects lacking renal disease or processes known to affect renal function has demonstrated that aging changes are less pronounced in healthy aged subjects. Nonetheless, understanding aging-induced renal changes may help to prevent life-threatening kidney disease. This review will focus on glomerular hemodynamics, and on renal sodium and potassium handling and diluting and concentrating ability.
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“The vulnerability of older adults to syncope increases because of age-associated cardiovascular and autonomic changes, decreased fluid conservation (45,671,676–678), and an increased probability of developing multiple concurrent morbidities (with their associated pharmacological treatments) that can overwhelm homeostasis.”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (2017) · cites this paper as [678]
In the citing paper
“The vulnerability of older adults to syncope increases because of age-associated cardiovascular and autonomic changes, decreased fluid conservation (45,671,676–678), and an increased probability of developing multiple concurrent morbidities (with their associated pharmacological treatments) that can overwhelm homeostasis.”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (2017) · cites this paper as [678]
In the citing paper
“The vulnerability of older adults to syncope increases because of age-associated cardiovascular and autonomic changes, decreased fluid conservation (45,671,676–678), and an increased probability of developing multiple concurrent morbidities (with their associated pharmacological treatments) that can overwhelm homeostasis.”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (2017) · cites this paper as [678]
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Cited by
Structural and Functional Changes With the Aging Kidney
Denic, A., Glassock, R. J., & Rule, A. D. (2016) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2015.08.004 · Cited by 819
2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.03.004 · Cited by 478
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000499 · Cited by 438
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000498 · Cited by 407
Cellular senescence in renal ageing and disease
Sturmlechner, I., Durik, M., Sieben, C. J., Baker, D. J., & van Deursen, J. M. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.183 · Cited by 345
Metadata
- Authors
- Esposito, C., & Dal Canton, A.
- Affiliations
- University of Pavia (IT)
- Unit of Nephrology, Dialysis and Transplantation, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia - Italy
- Corresponding author
- Esposito, Ciro
- ORCID
- Esposito, Ciro
- Venue
- Journal of Nephrology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-01-01
- Volume
- 23
- Issue
- S15
- Pages
- S41-S45
- ISSN
- 1121-8428 (ISSN-L)
- 1724-6059
- OpenAlex
- W32860048
- Cited by
- 39
- References
- 0
- Citations by year
- 2024: 4 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 2 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Nephrology (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- kidney aging, glomerular hemodynamics, renal sodium handling, renal potassium handling, renal concentrating ability, acute kidney injury, chronic kidney disease, healthy older adults, comorbidities
- MeSH terms
- Acid-Base Equilibrium, Age Factors, Aging, Animals, Glomerular Filtration Rate, Humans, Kidney, Kidney Diseases, Kidney Glomerulus, Kidney Tubules, Potassium, Renal Circulation, Sodium, Water-Electrolyte Balance
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Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Functional changes in the aging kidney. https://app.cochat.ai/papers/10.1093/joneph/23.s15.s41
- The paper
- Esposito, C., & Dal Canton, A. (2010). Functional changes in the aging kidney. Journal of Nephrology. https://doi.org/10.1093/joneph/23.s15.s41
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
