Autism and Environmental Genomics: Synergistic Systems Approaches to Autism Complexity
Abstract
Abstract This chapter outlines how genetic and environmental factors may converge on common mechanisms pertinent to neurodevelopmental disorders, and the ways that high heritability can involve not only high genetic but also high environmental contributions. The chapter is organized as follows. Part One discusses the mechanisms by which genome and environment work together. Part Two considers the methodological pitfalls in assessing relative contributions of genes, environment, and gene-environment interactions in a disorder with high heritability. Part Three focuses on research directions and resources.
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Environmental factors and gene-environment interplay in autism are understudied.
“Perhaps due to the frequently reported high heritability of autism [63], environmental factors and gene-environment interplay in autism are understudied [64] but may also help toward identification of subgroups.”
From Subgrouping the Autism Spectrum: Reflections on DSM-5 (2013) · cites this paper as [64]
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Subgrouping the Autism Spectrum: Reflections on DSM-5
Lai, M.-C., Lombardo, M. V., Chakrabarti, B., & Baron-Cohen, S. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001544 · Cited by 330 · see citing works
Wen, Y., Alshikho, M. J., & Herbert, M. R. (2016) · PLOS ONE · doi:10.1371/journal.pone.0153329 · Cited by 150 · see citing works
Self-citation
- Authors
- Corrales, M. A., & Herbert, M. R.
- ORCID
- Herbert, Martha R.
- Venue
- Autism Spectrum Disorders
- Publisher
- Oxford University Press
- Published
- 2011-05
- Pages
- 875-892
- OpenAlex
- W2503617203
- Cited by
- 14
- References
- 0
- Citations by year
- 2023: 4 · 2022: 2 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 2.74
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Oxford University Press eBooks (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- autism spectrum disorder, metagenomics, gene-environment interaction, heritability, neurodevelopmental disorders, environmental risk factors, genetic risk factors, methodological pitfalls, systems biology
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