Alcohol-Related Seizure Disorders
Abstract
This chapter describes the complex relationships between alcohol consumption and seizure disorders, which include alcohol withdrawal seizures and seizures that occur due to alcohol intoxication per se. We also present an update on the controversial but historically important concept of 'alcoholic epilepsy'. The current understanding of pathophysiological changes leading to alcohol withdrawal seizures is described in detail and illustrated by a typical case of excessive long-term alcohol consumption with multiple withdrawals and the associated medical and social sequelae. Potential causes and pathophysiological grounds for seizures due to alcohol intoxication are described in detail and a state-of-the-art understanding of the development of epilepsy in drinkers is presented. Special attention is paid to effects of alcohol consumption on existing seizure disorders. The differential diagnosis between different kinds of alcohol-related seizures and seizures in the context of epilepsy as well as appropriate management strategies are outlined.
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The association between alcohol use and seizures has been known since ancient times, with alcohol withdrawal seizures being the best studied and described aspect.
“The association between alcohol use and seizures has been known since ancient times, with alcohol withdrawal seizures being the best studied and described aspect 224, 225.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [224]
There was a dose-response relationship between alcohol use and epilepsy, with relative risks of 1.81 (95% CI 1.59-2.07), 2.04 (95% CI 2.00-2.97) and 3.27 (95% CI 2.52-4.26) for consuming 48, 72 and 96 g pure alcohol per day, respectively.
“In addition, there was a dose–response relationship, with RRs of 1.81 (95% CI = 1.59–2.07), 2.04 (95% CI = 2.00–2.97) and 3.27 (95% CI 2.52–4.26) for consuming 48, 72 and 96 g pure alcohol per day, respectively 224, 230.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [224]
A meta-analysis of the data on unprovoked seizures from six available studies showed an overall association between alcohol use and the risk of epilepsy with a pooled relative risk of 2.19 (95% CI 1.83-2.63).
“A meta‐analysis of the data on unprovoked seizures from six available studies showed an overall association between alcohol use and the risk of epilepsy with a pooled relative risk (RR) of 2.19 (95% CI = 1.83–2.63).”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [224]
Mendelian randomization studies were added to the methodological arsenal.
“Mendelian randomization studies were added to our methodological arsenal 224, 259”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [224]
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References 43 · Cited by 1
- Authors
- Samokhvalov, A. V., Araki, K. F., Selby, P., & Rehm, J.
- Venue
- Borderland of Epilepsy Revisited
- Publisher
- Oxford University Press
- Published
- 2012-10
- Pages
- 144-154
- OpenAlex
- W2494210633
- Cited by
- 1
- References
- 43
- Citations by year
- 2017: 1
- FWCI
- 0.00
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Oxford University Press eBooks (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- alcohol-related seizures, alcohol withdrawal seizures, alcohol intoxication, differential diagnosis of seizures, seizure control, chronic alcohol consumption
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