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Phylogenetic Analysis of the Vertebrate Galectin Family
Open accessAbstract
Galectins form a family of structurally related carbohydrate binding proteins (lectins) that have been identified in a large variety of metazoan phyla. They are involved in many biological processes such as morphogenesis, control of cell death, immunological response, and cancer. To elucidate the evolutionary history of galectins and galectin-like proteins in chordates, we have exploited three independent lines of evidence: (i) location of galectin encoding genes (LGALS) in the human genome; (ii) exon-intron organization of galectin encoding genes; and (iii) sequence comparison of carbohydrate recognition domains (CRDs) of chordate galectins. Our results suggest that a duplication of a mono-CRD galectin gene gave rise to an original bi-CRD galectin gene, before or early in chordate evolution. The N-terminal and C-terminal CRDs of this original galectin subsequently diverged into two different subtypes, defined by exon-intron structure (F4-CRD and F3-CRD). We show that all vertebrate mono-CRD galectins known to date belong to either the F3- or F4- subtype. A sequence of duplication and divergence events of the different galectins in chordates is proposed.
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Galectins: A family of animal β-galactoside-binding lectins
Barondes, S. H., Castronovo, V., Cooper, D. N. W., Cummings, R. D., Drickamer, K., Felzi, T., Gitt, M. A., Hirabayashi, J., Hughes, C., Kasai, K.-I., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90498-7 · Cited by 1,223 · cited 4×
“2; Barondes et al. 1994b; Gitt et al. 1998b).”
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Maejima, I., Takahashi, A., Omori, H., Kimura, T., Takabatake, Y., Saitoh, T., Yamamoto, A., Hamasaki, M., Noda, T., Isaka, Y., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.171 · Cited by 642
From lectin structure to functional glycomics: principles of the sugar code
Gabius, H.-J., André, S., Jiménez-Barbero, J., Romero, A., & Solís, D. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2011.01.005 · Cited by 483
Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal
Jia, J., Claude-Taupin, A., Gu, Y., Choi, S. W., Peters, R., Bissa, B., Mudd, M. H., Allers, L., Pallikkuth, S., Lidke, K. A., et al. (2020) · Developmental Cell · doi:10.1016/j.devcel.2019.10.025 · Cited by 434
Innate immune lectins kill bacteria expressing blood group antigen
Stowell, S. R., Arthur, C. M., Dias-Baruffi, M., Rodrigues, L. C., Gourdine, J.-P., Heimburg-Molinaro, J., Ju, T., Molinaro, R. J., Rivera-Marrero, C., Xia, B., et al. (2010) · Nature Medicine · doi:10.1038/nm.2103 · Cited by 324
Metadata
- Authors
- Houzelstein, D., Gonçalves, I. R., Fadden, A. J., Sidhu, S. S., Cooper, D. N. W., Drickamer, K., Leffler, H., & Poirier, F.
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-07
- Volume
- 21
- Issue
- 7
- Pages
- 1177-1187
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- OpenAlex
- W2133831816
- Cited by
- 273
- References
- 1
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Houzelstein, D., Gonçalves, I. R., Fadden, A. J., Sidhu, S. S., Cooper, D. N. W., Drickamer, K., Leffler, H., & Poirier, F. (2004). Phylogenetic Analysis of the Vertebrate Galectin Family. Molecular Biology and Evolution. https://doi.org/10.1093/molbev/msh082
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