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Fast Coalescent-Based Computation of Local Branch Support from Quartet Frequencies

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Sayyari, Erfan, Mirarab, Siavash·2016·Molecular Biology and Evolution

Abstract

Species tree reconstruction is complicated by effects of incomplete lineage sorting, commonly modeled by the multi-species coalescent model (MSC). While there has been substantial progress in developing methods that estimate a species tree given a collection of gene trees, less attention has been paid to fast and accurate methods of quantifying support. In this article, we propose a fast algorithm to compute quartet-based support for each branch of a given species tree with regard to a given set of gene trees. We then show how the quartet support can be used in the context of the MSC to compute (1) the local posterior probability (PP) that the branch is in the species tree and (2) the length of the branch in coalescent units. We evaluate the precision and recall of the local PP on a wide set of simulated and biological datasets, and show that it has very high precision and improved recall compared with multi-locus bootstrapping. The estimated branch lengths are highly accurate when gene tree estimation error is low, but are underestimated when gene tree estimation error increases. Computation of both the branch length and local PP is implemented as new features in ASTRAL.

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Metadata

Authors
Sayyari, E., & Mirarab, S.
Venue
Molecular Biology and Evolution
Published
2016-04-15
Volume
33
Issue
7
Pages
1654-1668
ISSN
  • 0737-4038 (ISSN-L)
  • 1537-1719
OpenAlex
W2277574918
Cited by
869
References
63
FWCI
27.24
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Fast Coalescent-Based Computation of Local Branch Support from Quartet Frequencies. https://app.cochat.ai/papers/10.1093/molbev/msw079
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Sayyari, E., & Mirarab, S. (2016). Fast Coalescent-Based Computation of Local Branch Support from Quartet Frequencies. Molecular Biology and Evolution. https://doi.org/10.1093/molbev/msw079

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