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Cited by 134Genomics and Phylogenetic StudiesEvolution and Paleontology StudiesGenetic diversity and population structure

Mapping Phylogenetic Trees to Reveal Distinct Patterns of Evolution

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Kendall, Michelle, Colijn, Caroline·2016·Molecular Biology and Evolution
DOI 10.1093/molbev/msw124PMC PMC5026250

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Abstract

UNLABELLED: Evolutionary relationships are frequently described by phylogenetic trees, but a central barrier in many fields is the difficulty of interpreting data containing conflicting phylogenetic signals. We present a metric-based method for comparing trees which extracts distinct alternative evolutionary relationships embedded in data. We demonstrate detection and resolution of phylogenetic uncertainty in a recent study of anole lizards, leading to alternate hypotheses about their evolutionary relationships. We use our approach to compare trees derived from different genes of Ebolavirus and find that the VP30 gene has a distinct phylogenetic signature composed of three alternatives that differ in the deep branching structure. KEY WORDS: phylogenetics, evolution, tree metrics, genetics, sequencing.

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Authors
Kendall, M., & Colijn, C.
Affiliations
Imperial College London (GB)
Corresponding author
Kendall, Michelle
ORCID
Venue
Molecular Biology and Evolution
Publisher
Oxford University Press (OUP)
Published
2016-06-24
Volume
33
Issue
10
Pages
2735-2743
ISSN
  • 0737-4038 (ISSN-L)
  • 1537-1719
DOI
10.1093/molbev/msw124
PMC
PMC5026250
OpenAlex
W2472378828
Cited by
134
References
2
Citations by year
2026: 4 · 2025: 14 · 2024: 15 · 2023: 7 · 2022: 12 · 2021: 16 · 2020: 18 · 2019: 15 · 2018: 18 · 2017: 14 · 2016: 1
FWCI
8.32
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Molecular Biology and Evolution (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • arXiv (Cornell University) (submittedVersion)
  • HighWire Press Open Archive (submittedVersion)
  • Spiral (Imperial College London) (submittedVersion, other-oa)
Funders
Engineering and Physical Sciences Research Council (EP/K026003/1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
  • Physical Sciences › Earth and Planetary Sciences › Paleontology › Evolution and Paleontology Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
Keywords
phylogenetic tree comparison, tree metrics, phylogenetic uncertainty, anoles, Ebolavirus
MeSH terms
Algorithms, Animals, Biological Evolution, Models, Genetic, Phylogeny, Statistics as Topic, Cluster Analysis, Evolution, Molecular

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