Statistical issues in the use of the comet assay

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Items 101–200 of 296

1. Acid sphingomyelinase as target of Lycium Chinense: promising new action for cell health
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2. Biomonitoring of genotoxicity of industrial fertilizer pollutants in Aiolopus thalassinus (Orthoptera: Acrididae) using alkaline comet assay
   Eman Alaaeldin Abdelfattah, Maria Augustyniak, Hesham A. Yousef · 2017 · Chemosphere
3. Alkaline comet assay results on fresh and one-year frozen whole blood in small volume without cryo-protection in a group of people with different health status
   Mirta Milić, Ivan Ožvald, Ivana Vinković Vrček, Marijana Vučić Lovrenčić, Višnja Oreščanin, Stefano Bonassi, Emilio Rojas del Castillo · 2019 · Mutation Research/Genetic Toxicology and Environmental Mutagenesis
4. Genotoxic and Antigenotoxic Activity of Acerola (Malpighia glabra L.) Extract in Relation to the Geographic Origin
   Roberta da Silva Nunes, Vivian Francília Silva Kahl, Merielen da Silva Sarmento, Marc François Richter, Juan Andrés Abin‐Carriquiry, Marcela María Martinez, Alexandre de Barros Falcão Ferraz, Juliana da Silva · 2012 · Phytotherapy Research
5. The effect of insecticides chlorpyrifos, α-cypermethrin and imidacloprid on primary DNA damage, TP 53 and c- Myc structural integrity by comet-FISH assay
   Davor Želježić, Benjamin Vinković, Vilena Kašuba, Nevenka Kopjar, Mirta Milić, Marin Mladinić · 2017 · Chemosphere
6. Methamphetamine (“crystal meth”) causes induction of DNA damage and chromosomal aberrations in human derived cells
   Nathalie Ropek, Halh Al-Serori, Miroslav Mišík, Armen K. Nersesyan, Harald H. Sitte, Andrew Richard Collins, Sergey A. Shaposhnikov, Siegfried Knasmüller, Michael Kundi, Franziska Ferk · 2019 · Food and Chemical Toxicology
7. The Wing-Spot and the Comet Tests as Useful Assays Detecting Genotoxicity in Drosophila
   Ricard Marcos, Erico R. Carmona · 2013 · Methods in molecular biology
8. Analysis of Nanoparticle-Induced DNA Damage by the Comet Assay
   Julia Catalán, Satu Suhonen, Anna Huk, Mária Dušinská · 2014 · Methods in pharmacology and toxicology
9. Integrated study of genotoxicity biomarkers in schoolchildren and inhalable particles in areas under petrochemical influence
   Andréia Torres Lemos, Clarice Torres de Lemos, Mariana Vieira Coronas, Jéssica Rosiak da Rocha, Vera Maria Ferrão Vargas · 2020 · Environmental Research
10. Physical Exercise and DNA Injury
    Elisa Danese, Giuseppe Lippi, Fabián Sanchis‐Gomar, Giorgio Brocco, Manfredi Rizzo, Maciej Banach, Martina Montagnana · 2017 · Advances in clinical chemistry
11. Genome size and sensitivity to DNA damage by X-rays—plant comets tell the story
    John Einset, Andrew Richard Collins · 2017 · Mutagenesis
12. Validation of a fully automated COMET assay: 1.75 million single cells measured over a 5 year period
    Albert Rosenberger, Ute Rößler, Sabine Hornhardt, Wiebke Sauter, Heike Bickeböller, H.‐Erich Wichmann, Maria Gomolka · 2011 · DNA repair
13. Monitoring of genotoxicity in marine zooplankton induced by toxic metals in Ennore estuary, Southeast coast of India
    Prasun Goswami, Subramani Thirunavukkarasu, Nallamuthu Godhantaraman, Natesan Munuswamy · 2014 · Marine Pollution Bulletin
14. Edaravone protects human peripheral blood lymphocytes from γ-irradiation-induced apoptosis and DNA damage
    Liming Chen, Yinghui Liu, Liangliang Dong, Xiaoxia Chu · 2014 · Cell Stress and Chaperones
15. Phase I clinical trial of the base excision repair inhibitor methoxyamine in combination with fludarabine for patients with advanced hematologic malignancies
    Paolo Fabrizio Caimi, Brenda Cooper, Basem Magdy William, Afshin Dowlati, Paul M. Barr, Pingfu Fu, John J. Pink, Yan‐Ming Xu, Hillard Michael Lazarus, Marcos J. G. De Lima et al. · 2017 · Oncotarget
16. Loss of genetic integrity in artificially aged seed lots of rice (Oryza sativa L.) and common bean (Phaseolus vulgaris L.)
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17. Evaluation of the nitrosamine impurities of ACE inhibitors using computational, in vitro, and in vivo methods demonstrate no genotoxic potential
    Jennifer R. Cheung, Krista L. Dobo, Shaofei Zhang, Raphael Nudelman, Friedemann Schmidt, Jan Wenzel, Andreas Czich, Maik Schuler · 2024 · Environmental and Molecular Mutagenesis
18. DNA Electrophoretic Migration Patterns Change after Exposure of Jurkat Cells to a Single Intense Nanosecond Electric Pulse
    Stefania Romeo, Luigi Zeni, Maurizio Sarti, Anna Sannino, Maria Rosaria Scarfı̀, P. Thomas Vernier, Olga Zeni · 2011 · PLoS ONE
19. Dose-related genotoxic effect of T-2 toxin measured by comet assay using peripheral blood mononuclear cells of healthy pigs
    Katalin Horvatovich, Dóra Hafner, Zsófia Blochné Bodnár, Gergely Berta, Csaba Hancz, Mike Francis Dutton, Melinda Kovács · 2013 · Acta Veterinaria Hungarica
20. Comparison of the toxicity of pure compounds and commercial formulations of imidacloprid and acetamiprid on HT-29 cells: Single and mixture exposure
    Merve Baysal, Özlem Atlı Eklioğlu · 2021 · Food and Chemical Toxicology
21. Melatonin attenuates phenytoin sodium-induced DNA damage
    Ufuk Erenberk, Ruşen Dündaröz, Özlem Gök, Ömer Uysal, Sami Ağuş, Adnan Yüksel, Bayram Yılmaz, Ülkan Kılıç · 2013 · Drug and Chemical Toxicology
22. Long-term biomonitoring of breast cancer patients under adjuvant chemotherapy: the comet assay as a possible predictive factor
    Esther Uriol, Marta Sierra, Miguel Angel Comendador, J. Fra, Pablo Martínez‐Camblor, A.J. Lacave, Luisa María Sierra · 2012 · Mutagenesis
23. Homocysteine contribution to DNA damage in cystathionine β-synthase-deficient patients
    Camila Simioni Vanzin, Vanusa Manfredini, Ana Eveline Marinho, Giovana Brondani Biancini, Graziela S. Ribas, Marion Deon, Ângela Terezinha de Souza Wyse, Moaçir Wajner, Carmen Regla Vargas · 2014 · Gene
24. Assessing the genotoxicity of N‐nitrosodiethylamine with three in vivo endpoints in male Big Blue® transgenic and wild‐type C57BL/6N mice
    Shaofei Zhang, S. Coffing, W. C. Gunther, M. Homiski, R. Spellman, Phu Van, Maik Schuler · 2024 · Environmental and Molecular Mutagenesis
25. Desenvolvimento e validação de técnica quantitativa de análise de imagem para avaliação do teste do cometa corado pela prata
    Gabrielli Brianezi, João Lauro Viana de Camargo, Hélio Amante Miot · 2009 · Jornal Brasileiro de Patologia e Medicina Laboratorial
26. Diepoxybutane induces the formation of DNA–DNA rather than DNA–protein cross-links, and single-strand breaks and alkali-labile sites in human hepatocyte L02 cells
    Ying Wen, Panpan Zhang, Jing An, Yingxin Yu, Minghong Wu, Guoying Sheng, Jiamo Fu, Xinyu Zhang · 2011 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
27. Direct use of the comet assay to study cell cycle distribution and its application to study cell cycle-dependent DNA damage formation
    Marcin K. Kruszewski, Teresa Iwaneñko, Eugeniusz Krzysztof Machaj, Tomasz Ołdak, Maria Wojewódzka, Lucyna Kapka‐Skrzypczak, Zygmunt Pojda · 2012 · Mutagenesis
28. Assessment of the genotoxic and mutagenic properties of Himatanthus articulatus bark extracts used as phytotherapeutic drug in the Amazon
    Sebastião de O. Rebouças, Juliana da Silva, Ricardo S. Bertoni, Natália Decker, Marcela Silva dos Santos, Raíssa Rebés Rossatto, Dione Silva Corrêa, Alexandre de Barros Falcão Ferraz · 2013 · Journal of Ethnopharmacology
29. DNA damage induced by three major metabolites of 1,3-butadiene in human hepatocyte L02 cells
    Panpan Zhang, Ying Wen, Jing An, Yingxin Yu, Minghong Wu, Xinyu Zhang · 2012 · Mutation Research/Genetic Toxicology and Environmental Mutagenesis
30. Evaluation of multi-organ DNA damage by comet assay from 28 days repeated dose oral toxicity test in mice: A practical approach for test integration in regulatory toxicity testing
    Sapana Kushwaha, Durga Nand Tripathi, Ajit Vikram, Poduri Ramarao, Gopabandhu Jena · 2010 · Regulatory Toxicology and Pharmacology
31. A pilot in vivo evaluation of Sb(III) and Sb(V) genotoxicity using comet assay and micronucleus test on the freshwater fish, silver perch Bidyanus bidyanus (Mitchell, 1838)
    Maximilian Obinna Obiakor, Matthew Kevin Tighe, Lily L. Pereg, William A. Maher, Anne M. Taylor, Susan Caroline Wilson · 2021 · Environmental Advances
32. Investigation on the mechanisms of genotoxicity of butadiene, styrene and their combination in human lymphocytes using the Comet assay
    Eduardo Cemeli, Ekaterina T. Mirkova, Giorgia Chiuchiarelli, Elena Alexandrova, Diana C. Anderson · 2009 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
33. Oral health status and its determinants in children with leukaemia at the Radiation and Isotope Center Khartoum, Khartoum State, Sudan
    Moataz Ali, Nazik Mostafa Nurelhuda · 2019 · Sudanese Journal of Paediatrics
34. Validation of Gelbond® high‐throughput alkaline and Fpg‐modified comet assay using a linear mixed model
    Hervé Perdry, Kristine B. Gützkow, Marianne Chevalier, Laurence Therese HUC, Gunnar Brunborg, Elisa A. Boutet-Robinet · 2018 · Environmental and Molecular Mutagenesis
35. Guidance for publishing comet assay results
    Gunnar Brunborg, Andrew Richard Collins · 2020 · Mutation Research/Genetic Toxicology and Environmental Mutagenesis
36. Two new approaches to improve the analysis of BALB/c 3T3 cell transformation assay data
    Sebastian Hoffmann, Ludwig A. Hothorn, Lutz Edler, André Kleensang, Masaya Suzuki, Pascal Phrakonkham, Daniel Gerhard · 2011 · Mutation Research/Genetic Toxicology and Environmental Mutagenesis
37. Automated segmentation of comet assay images using Gaussian filtering and fuzzy clustering
    Mario Sansone, Olga Zeni, Giovanni Esposito · 2012 · Medical & Biological Engineering & Computing
38. DNA repair after X-irradiation: lessons from plants
    John Einset, Andrew Richard Collins · 2014 · Mutagenesis
39. DNA damage response in imatinib resistant chronic myeloid leukemia K562 cells
    Joana Dinis, Vânia Maria de Souza Silva, Marta Gromicho, Célia Martins, A. Laires, Purificação Tavares, Paula Rendeiro, Fátima Torres, José Rueff, António Sebastião Rodrigues · 2012 · Leukemia & lymphoma/Leukemia and lymphoma
40. Factors influencing heterogeneity of radiation-induced DNA-damage measured by the alkaline comet assay
    Clemens Seidel, Christine Lautenschläger, Jürgen Dunst, Arndt‐Christian Müller · 2012 · Radiation Oncology
41. Hexachlorobenzene exerts genotoxic effects in a humpback whale cell line under stable exposure conditions
    Jenny Maner, Michael Burkard, Juan C. Cassano, Susan Bengtson Nash, Kristin Schirmer, Marc J.‐F. Suter · 2019 · RSC Advances
42. Potentiating toxicological interaction of single-walled carbon nanotubes with dissolved metals
    Majed Al‐Shaeri, Dina Ahmed, Fiona McCluskey, Gavin Turner, Lynn Paterson, Elisabeth A. Dyrynda, Mark G.J. Hartl · 2013 · Environmental Toxicology and Chemistry
43. Cellular Responses Induced by Zinc in Zebra Mussel Haemocytes. Loss of DNA Integrity as a Cellular Mechanism to Evaluate the Suitability of Nanocellulose-Based Materials in Nanoremediation
    Patrizia Guidi, Margherita Bernardeschi, Mara Palumbo, Vittoria Scarcelli, Massimo Genovese, Giuseppe Protano, Valentina Vitiello, Lorenzo Pontorno, Lisa Bonciani, Isabella Buttino et al. · 2021 · Nanomaterials
44. Fluctuating estuarine conditions are not confounding factors for the Comet assay assessment of DNA damage in the mussel Mytilus edulis
    Rupika Singh, Mark G.J. Hartl · 2012 · Ecotoxicology
45. Studying the mixture effects of brominated flame retardants and metal ions by comet assay
    Biyan Wang, Haiyan Wang, Daxiong Han, Jinming Chen, Yan Yin · 2020 · Environmental Pollution
46. Optimization of the harvesting and freezing conditions of human cell lines for DNA damage analysis by the alkaline comet assay
    Maria João Bessa, Fátima Brandão, Micaela Machado Querido, Carla Costa, Cristiana Costa Pereira, Vanessa Valdiglesias, Blanca Laffón, Marie Carrière, João Paulo Teixeira, Sónia Fraga · 2018 · Mutation Research/Genetic Toxicology and Environmental Mutagenesis
47. Synephrine and caffeine combination promotes cytotoxicity, DNA damage and transcriptional modulation of apoptosis-related genes in human HepG2 cells
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48. Metal enriched quasi-ultrafine particles from stainless steel gas metal arc welding induced genetic and epigenetic alterations in BEAS-2B cells
    Jamila Boudjema, B. Lima, Céline Grare, L. Alleman, Davy Rousset, Espéranza Perdrix, Djamal Achour, Sébastien Anthérieu, Anne Platel, Fabrice Nesslany et al. · 2021 · NanoImpact
49. Use of the single cell gel electrophoresis assay for the detection of DNA-protective dietary factors: Results of human intervention studies
    Miroslav Mišík, Marlen Staudinger, Michael Kundi, Nadine Worel, Armen K. Nersesyan, Franziska Ferk, Mária Dušinská, Amaya Azqueta, Peter Möller, Siegfried Knasmüller · 2023 · Mutation Research/Reviews in Mutation Research
50. Genotoxicity of crude extracts of cyanobacteria from Taihu Lake on carp (Cyprinus carpio)
    Qin Wu, Mei Li, Xiangyu Gao, John Paul Giesy, Yibin Cui, Liuyan Yang, Zhiming Kong · 2011 · Ecotoxicology
51. EXPRESSION OF CONCERN: Photodynamic therapy with 5‐aminolaevulinic acid and DNA damage: unravelling roles of p53 and ABCG 2
    Ilaria Postiglione, Federica Barra, Salvatore M. Aloj, Giuseppe Alberto Palumbo · 2016 · Cell Proliferation
52. In vivo Comet assay – statistical analysis and power calculations of mice testicular cells
    Merete Kjær Hansen, Anoop Kumar Sharma, Marianne Dybdahl, Julie Boberg, Murat Külahçı · 2014 · Mutation Research/Genetic Toxicology and Environmental Mutagenesis
53. Re‐Evaluating Acceptable Intake: A Comparative Study of N‐Nitrosomorpholine and N‐Nitroso Reboxetine Potency
    Shaofei Zhang, Jennifer R. Cheung, Jakub Kostal, Adelina M. Voutchkova‐Kostal, Maik Schuler · 2025 · Environmental and Molecular Mutagenesis
54. Cytotoxicity, genotoxicity, and mutagenicity of 1-chloro-2-hydroxy-3-butene and 1-chloro-3-buten-2-one, two alternative metabolites of 1,3-butadiene
    Xin-Jie Liu, Fang-Mao Zeng, Jing An, Yingxin Yu, Xinyu Zhang, Adnan A. Elfarra · 2013 · Toxicology and Applied Pharmacology
55. Sampling uncertainty in medical research
    Jonas Ranstam · 2009 · Osteoarthritis and Cartilage
56. In vitro genotoxicity/antigenotoxicity testing of some conjugated linoleic acid isomers using comet assay
    Francesca Blasi, Luca Dominici, Massimo Moretti, Milena Villarini, Silvia Maurelli, Maria Stella Simonetti, Pietro Damiani, Lina Cossignani · 2012 · European Journal of Lipid Science and Technology
57. Statistical evaluation of the in vivo micronucleus assay
    Ludwig A. Hothorn, Daniel Gerhard · 2008 · Archives of Toxicology
58. The Comet Assay in Marine Animals
    Patrizia Guidi, Brett P. Lyons, Giada Frenzilli · 2019 · Methods in molecular biology
59. Assessment of Genotoxicity in Human Cells Exposed to Modulated Electromagnetic Fields of Wireless Communication Devices
    David Schuermann, Christina Ziemann, Zeinab Barekati, Myles H. Capstick, A. Oertel, Frauke Focke, Manuel Murbach, Niels Kuster, Clemens Dasenbrock, Primo Schär · 2020 · Genes
60. Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected
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61. Does the crystal habit modulate the genotoxic potential of silica particles? A cytogenetic evaluation in human and murine cell lines
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62. The Concurrence of Hypercholesterolemia and Aging Promotes DNA Damage in Apolipoprotein E-Deficient Mice
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63. Toxicity of Pre-heated Composites Polymerized Directly and Through CAD/CAM Overlay
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64. The Comet Assay in Marine Animals
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65. Simultaneous removal of dihydroxybenzenes and toxicity reduction by Penicillium chrysogenum var. halophenolicum under saline conditions
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66. Genotoxicity Evaluation of the Soybean Isoflavone Genistein in Human Papillary Thyroid Cancer Cells. Study of Its Potential Use in Thyroid Cancer Therapy
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67. Applications of the Comet Assay in Human Biomonitoring
    Andrew Richard Collins, Mária Dušinská · 2009 · Royal Society of Chemistry eBooks
68. Mutagenicity Testing
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69. Persistent Organochlorine Pollutants in Placentas Sampled from Women in Croatia and an Evaluation of Their DNA Damaging Potential In Vitro
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70. DNA damage in blood leukocytes from mice irradiated with accelerated carbon ions with an energy of 450 MeV/nucleon
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71. Statistical Analysis of Comet Assay Data
    David Paul Lovell · 2009 · Royal Society of Chemistry eBooks
72. Porous Maltodextrin-Based Nanoparticles: A Safe Delivery System for Nasal Vaccines
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73. Influence of ozonation and UV/H2O2 on the genotoxicity of secondary wastewater effluents
    Laís Roberta Deroldo Sommaggio, Dânia Elisa Christofoletti Mazzeo, Jacqueline A. Malvestiti, Renato F. Dantas, Maria Aparecida Marin‐Morales · 2024 · The Science of The Total Environment
74. Genotoxicity Assessment of Metal-Based Nanocomposites Applied in Drug Delivery
    Sara Mineli Caioni Cardoso, Classius Ferreira da Silva, Patrícia B. Severino, Amélia Maria Silva, Selma B. Souto, Aleksandra Zielińska, Jacek Karczewski, Eliana B. Souto · 2021 · Materials
75. Evaluation of the Bronchorelaxant, Genotoxic, and Antigenotoxic Effects ofCassia alataL.
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76. Bioactivity of Satureja montana L. honey extracts and their profile screening
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77. In vitrogenoprotective and genotoxic effect of nicotine on human leukocytes evaluated by the comet assay
    Robert Sobkowiak, Jakub Musidlak, Andrzej Lesicki · 2013 · Drug and Chemical Toxicology
78. Comet and cytogenetic tests as tools for evaluating genomic instability in seeds of Oryza sativa L. and Phaseolus vulgaris L. from gene banks
    Alisson Ferreira Dantas, Renata Miranda Lopes, Maria Luiza Fascineli, Solange Carvalho Barrios Roveri José, Juliano Gomes Pádua, Marcos A. Gimenes, César Koppe Grisólia · 2018 · Genetics and Molecular Biology
79. Reducing risk of false positives in the in vivo comet assay and improving result reliability
    Marie Z. Vasquez, Nicole E. Dewhurst · 2024 · Mutation Research/Genetic Toxicology and Environmental Mutagenesis
80. Evaluation of the Pig‐a, micronucleus, and comet assay endpoints in a 28‐day study with ethyl methanesulfonate
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81. The antigenotoxic activity of latex from Himatanthus articulatus
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82. The level of DNA damage in mouse hematopoietic cells and in frog and human blood cells, as induced by the action of reactive oxygen species in vitro
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83. The Wing-Spot and the Comet Tests as Useful Assays for Detecting Genotoxicity in Drosophila
    Ricard Marcos, Erico R. Carmona · 2019 · Methods in molecular biology
84. In vivo Mammalian Alkaline Comet Assay: Method Adapted for Genotoxicity Assessment of Nanomaterials
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85. The Comet Assay: High Throughput Use of FPG
    Amaya Azqueta, Andrew Richard Collins · 2014 · Methods in pharmacology and toxicology
86. Use of native species Crenicichla menezesi (Ariidae) as a model for in situ evaluation of genotoxicity in surface water
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87. Joint modeling of hierarchically clustered and overdispersed non‐gaussian continuous outcomes for comet assay data
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88. In vivo alkaline comet assay: Statistical considerations on historical negative and positive control data
    Timur Tug, Julia Duda, Max Menssen, Shannon Wilson Bruce, Frank Bringezu, Martina Dammann, Roland Frötschl, Volker Harm, Katja Ickstadt, Bernd‐Wolfgang Igl et al. · 2024 · Regulatory Toxicology and Pharmacology
89. The impact of EGFR stimulation and inhibition on BPDE induced DNA fragmentation in oral/oropharyngeal mucosa in vitro
    Philipp Baumeister, Katharina Heinrich, Melanie Märte, Maximilian Reiter, Sabina Schwenk‐Zieger, Ulrich Harréus · 2011 · Oral Oncology
90. A Bayesian, Generalized Frailty Model for Comet Assays
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91. Genotoxic effects of intermediate frequency magnetic fields on blood leukocytes in vitro
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92. V-79 Chinese Hamster cells irradiated with antiprotons, a study of peripheral damage due to medium and long range components of the annihilation radiation
    Sandra Kovacevic, Niels Bassler, Oliver Hartley, Helge Knudsen, Sanja Vranješ‐Đurić, Vera Garaj‐Vrhovac, Michael H. Holzscheiter · 2009 · International Journal of Radiation Biology
93. Single and combined genotoxicity effects of six pollutants on THP-1 cells
    Dan Xiao, Haiyan Wang, Daxiong Han · 2016 · Food and Chemical Toxicology
94. Investigations of the genotoxic properties of two synthetic cathinones (3-MMC, 4-MEC) which are used as psychoactive drugs
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95. Advancing Comet Assay Sensitivity and Specificity in Genotoxicity Research: Leveraging Artificial Intelligence and Machine Learning for In Vitro Toxicology
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96. In Vitro and In Vivo Investigations into the Potential of Quinazoline and Quinoline Derivatives as NorA Efflux Pump Inhibitors Against Resistant Staphylococcus aureus Strains
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97. Genotoxicity, mutagenicity and immunotoxicity assessment of microplastics and nanoparticle mixture in bullfrog tadpoles
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99. DNA damage caused by inorganic particulate matter on Raji and HepG2 cell lines exposed to ultraviolet radiation
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100. A novel ruthenium(II)–polypyridyl complex inhibits cell proliferation and induces cell apoptosis by impairing DNA damage repair
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