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Graphic methods to determine the function of nucleic acid sequences
Open accessAbstract
We describe an interactive computer program (ANALYSEQ) that is used from a simple graphics terminal. The main purpose of the program is to determine the function of nucleic acid sequences but it also offers the simpler listing, searching and counting options. It contains methods to locate genes by looking for the effects that coding for a protein has on the coding sequence, to locate tRNA genes by looking for secondary structure and conserved bases, and methods to locate signals such as promoters. Techniques to identify unusual regions of sequence and to search for potential Z DNA-forming regions are also included. Most of the routines produce graphical output which gives ease of interpretation and allows superposition of several independent forms of analysis.
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Cited by
Arriza, J. L., Weinberger, C., Cerelli, G., Glaser, T. M., Handelin, B. L., Housman, D. E., & Evans, R. M. (1987) · Science · doi:10.1126/science.3037703 · Cited by 1,946
Replacing the complementarity-determining regions in a human antibody with those from a mouse
Jones, P. T., Dear, P. H., Foote, J., Neuberger, M. S., & Winter, G. (1986) · Nature · doi:10.1038/321522a0 · Cited by 1,406
Cortes, J., Haydock, S. F., Roberts, G. A., Bevitt, D. J., & Leadlay, P. F. (1990) · Nature · doi:10.1038/348176a0 · Cited by 624
Kidd, S., Kelley, M. R., & Young, M. W. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.9.3094 · Cited by 425
Whitchurch, C. B., Hobbs, M., Livingston, S. P., Krishnapillai, V., & Mattick, J. S. (1991) · Gene · doi:10.1016/0378-1119(91)90221-v · Cited by 274
Metadata
- Authors
- Staden, R.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1984
- Volume
- 12
- Issue
- 1Part2
- Pages
- 521-538
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2045162258
- Cited by
- 360
- References
- 0
- FWCI
- 20.23
- Type
- journal article
- Language
- en
- Open access
- green
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