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Cited by 504

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Human Lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization

Open access
Nedwin, Glenn E., Naylor, Susan L., Sakaguchi, Alan Y., Smith, Douglas, Jarrett-Nedwin, Julie, Pennica, Diane, Goeddel, David V., Gray, Patrick W.·1985·Nucleic Acids Research

Abstract

Human Tumor Necrosis Factor and Lymphotoxin are cytotoxic proteins which have similar biological activities and share 30 percent amino acid homology. The single copy genes which encode these proteins share several structural features: each gene is approximately three kilobase pairs in length and is interrupted by three introns. In addition, these genes are closely linked and have been mapped to human chromosome 6. However, only the last exons of both genes, which code for more than 80 percent of each secreted protein, are significantly homologous (56 percent).

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Crossref · 10.1093/nar/13.17.6361

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Metadata

Authors
Nedwin, G. E., Naylor, S. L., Sakaguchi, A. Y., Smith, D., Jarrett-Nedwin, J., Pennica, D., Goeddel, D. V., & Gray, P. W.
Venue
Nucleic Acids Research
Published
1985
Volume
13
Issue
17
Pages
6361-6373
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2096158027
Cited by
504
References
2
FWCI
7.88
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Human Lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization. https://app.cochat.ai/papers/10.1093/nar/13.17.6361
The paper
Nedwin, G. E., Naylor, S. L., Sakaguchi, A. Y., Smith, D., Jarrett-Nedwin, J., Pennica, D., Goeddel, D. V., & Gray, P. W. (1985). Human Lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization. Nucleic Acids Research. https://doi.org/10.1093/nar/13.17.6361

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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