The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The human urokinase-plasminogen activator gene and its promoter
Open accessAbstract
The urokinase type of plasminogen activator (uPA) is subject to regulation by hormones, phorbol esters and oncogenic transformation. This enzyme has been suggested to play a key role in processes involving cell migration and tissue remodeling, and to be essential for tumor metastasis. In order to study these processes, we have isolated the human uPA gene, and have determined its entire nucleotide sequence. The gene is organized in 11 exons and is 6.4 kb long. The 5' end of uPA mRNA has been determined by both S1 mapping and primer extension experiments. A fragment of 800 bp containing the entire 5' flanking region shows promoter activity when introduced upstream of a bacterial chloramphenicol acetyltransferase gene and introduced into human cells. The hexanucleotide sequence GGCGGG, previously found at similar regions in several viral and eukaryotic promoters and shown to be essential for promoter activity (McKnight et al. (1984) Cell, 37, 253-262), is repeated three times between the CAAT and the TATA boxes.
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Cites
Gilbert, W. (1978) · Nature · doi:10.1038/271501a0 · Cited by 2,300
Ny, T., Elgh, F., & Lund, B. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.17.5355 · Cited by 299
Cited by
CpG Islands in vertebrate genomes
Gardiner-Garden, M., & Frommer, M. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90689-9 · Cited by 3,353
Cell-Associated Plasminogen Activation: Regulation and Physiological Functions
Saksela, O., & Rifkin, D. B. (1988) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.04.110188.000521 · Cited by 818
An evaluation of the molecular clock hypothesis using mammalian DNA sequences
Li, W.-H., Tanimura, M., & Sharp, P. M. (1987) · Journal of Molecular Evolution · doi:10.1007/bf02603118 · Cited by 450
The plasminogen activator system: biology and regulation
Irigoyen, J. P., Muñoz-Cánoves, P., Montero, L., Koziczak, M., & Nagamine, Y. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000615 · Cited by 368
Autocrine saturation of pro-urokinase receptors on human A431 cells
Stoppelli, M. P., Tacchetti, C., Cubellis, M. V., Corti, A., Hearings, V. J., Cassani, G., Appella, E., & Blasi, F. (1986) · Cell · doi:10.1016/0092-8674(86)90782-8 · Cited by 355
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Metadata
- Authors
- Riccio, A., Grimaldi, G., Verde, P., Sebastio, G., Boast, S., & Blasi, F.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1985
- Volume
- 13
- Issue
- 8
- Pages
- 2759-2771
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2019728202
- Cited by
- 207
- References
- 2
- FWCI
- 11.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Riccio, A., Grimaldi, G., Verde, P., Sebastio, G., Boast, S., & Blasi, F. (1985). The human urokinase-plasminogen activator gene and its promoter. Nucleic Acids Research. https://doi.org/10.1093/nar/13.8.2759
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