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Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates
Open accessAbstract
The previously presented consensus sequence for eukaryotic translation initiation sites by Kozak was derived substantially from vertebrate mRNA sequences. Drosophila nuclear genes exhibit a significantly different translation start consensus sequence. These differences probably do not represent mechanistic differences in translation initiation inasmuch as both taxa exhibit identical preferences and restrictions at the crucial -3 position. Using more conservative criteria for the assignment of consensus the following consensus sequences were derived: vertebrate--CANCAUG and Drosophila--CAAAACAUG.
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Citations
Cites
Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
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Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4
Böhni, R., Riesgo-Escovar, J., Oldham, S., Brogiolo, W., Stocker, H., Andruss, B. F., Beckingham, K., & Hafen, E. (1999) · Cell · doi:10.1016/s0092-8674(00)80799-0 · Cited by 835
Hay, B., Jan, L. Y., & Jan, Y. N. (1988) · Cell · doi:10.1016/0092-8674(88)90216-4 · Cited by 616
Tschiersch, B., Hofmann, A., Krauss, V., Dorn, R., Korge, G., & Reuter, G. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06693.x · Cited by 567
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Field, C. M., & Alberts, B. M. (1995) · The Journal of cell biology · doi:10.1083/jcb.131.1.165 · Cited by 438
Metadata
- Authors
- Cavener, D. R.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1987
- Volume
- 15
- Issue
- 4
- Pages
- 1353-1361
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2022236187
- Cited by
- 955
- References
- 1
- FWCI
- 23.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cavener, D. R. (1987). Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates. Nucleic Acids Research. https://doi.org/10.1093/nar/15.4.1353
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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