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A 13 bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor
Open accessAbstract
Sequences located upstream of the transcription initiation site of the Xenopus vitellogenin A2 (vit A2) gene contain a hormone dependent enhancer that confers estrogen control to the heterologous thymidine kinase (tk) promoter. As a minimal functional estrogen responsive element (ERE), we have defined the 13 bp palindrome GGTCACAGTGACC. This ERE binds estrogen receptor preferentially in vitro. Although the ERE shares some structural features with the glucocorticoid responsive element (GRE) it is distinct from this element since it neither binds glucocorticoid receptor in vitro nor does it confer glucocorticoid inducibility to a fusion gene. Point mutations within the ERE decrease its affinity for the estrogen receptor and result in a complete loss of estrogen inducibility.
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Cited by
Kastner, P., Krust, A., Turcotte, B., Stropp, U., Tora, L., Gronemeyer, H., & Chambon, P. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08280.x · Cited by 1,534
CDK-Independent Activation of Estrogen Receptor by Cyclin D1
Zwijsen, R. M. L., Wientjens, E., Klompmaker, R., van der Sman, J., Bernards, R., & Michalides, R. J. A. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81879-6 · Cited by 720
Denison, M. S., Fisher, J. M., & Whitlock, J. P. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77819-3 · Cited by 451
Vamvakopoulos, N. C., & Chrousos, G. P. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116782 · Cited by 422
Commonly occurring plant flavonoids have estrogenic activity.
Miksicek, R. J. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13162-3 · Cited by 367
Metadata
- Authors
- Klein-Hitpass, L., Ryffel, G. U., Heitlinger, E., & Cato, A. C. B.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1988
- Volume
- 16
- Issue
- 2
- Pages
- 647-663
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2048595449
- Cited by
- 429
- References
- 0
- FWCI
- 20.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Klein-Hitpass, L., Ryffel, G. U., Heitlinger, E., & Cato, A. C. B. (1988). A 13 bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor. Nucleic Acids Research. https://doi.org/10.1093/nar/16.2.647
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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