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Cited by 5,393

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Multiple sequence alignment with hierarchical clustering

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Corpet, F.·1988·Nucleic Acids Research

Abstract

An algorithm is presented for the multiple alignment of sequences, either proteins or nucleic acids, that is both accurate and easy to use on microcomputers. The approach is based on the conventional dynamic-programming method of pairwise alignment. Initially, a hierarchical clustering of the sequences is performed using the matrix of the pairwise alignment scores. The closest sequences are aligned creating groups of aligned sequences. Then close groups are aligned until all sequences are aligned in one group. The pairwise alignments included in the multiple alignment form a new matrix that is used to produce a hierarchical clustering. If it is different from the first one, iteration of the process can be performed. The method is illustrated by an example: a global alignment of 39 sequences of cytochrome c.

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Metadata

Authors
Corpet, F.
Venue
Nucleic Acids Research
Published
1988-11-25
Volume
16
Issue
22
Pages
10881-10890
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2034767282
Cited by
5,393
References
1
FWCI
9.40
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Multiple sequence alignment with hierarchical clustering. https://app.cochat.ai/papers/10.1093/nar/16.22.10881
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Corpet, F. (1988). Multiple sequence alignment with hierarchical clustering. Nucleic Acids Research. https://doi.org/10.1093/nar/16.22.10881

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