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Viral proteins containing the purine NTP-binding sequence pattern
Open accessAbstract
A compilation is presented of viral proteins containing the NTP-binding sequence pattern, and criteria are suggested for assessment of the functional significance of the occurrence of this pattern in protein sequences. It is shown that the distribution of NTP-binding pattern-containing proteins through the viral kingdom is strongly non-random. Sequence comparisons led to delineation of several families of these proteins, some of which could be brought together into superfamilies including also cellular proteins. The available biochemical evidence is compatible with the proposal that viral proteins in which the NTP-binding pattern is evolutionarily conserved might all be NTPases involved in: i) duplex unwinding during DNA and RNA replication, transcription, recombination and repair, and possibly mRNA translation; ii) DNA packaging, and iii) dNTP generation.
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Cited by
Did DNA replication evolve twice independently?
Leipe, D. D., Aravind, L., & Koonin, E. V. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.17.3389 · Cited by 351
Self-citationRubin, D. M., Glickman, M. H., Larsen, C. N., Dhruvakumar, S., & Finley, D. (1998) · The EMBO Journal · doi:10.1093/emboj/17.17.4909 · Cited by 297
Metadata
- Authors
- Gorbalenya, A. E., & Koonin, E. V.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1989
- Volume
- 17
- Issue
- 21
- Pages
- 8413-8438
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2126505139
- Cited by
- 433
- References
- 0
- FWCI
- 9.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gorbalenya, A. E., & Koonin, E. V. (1989). Viral proteins containing the purine NTP-binding sequence pattern. Nucleic Acids Research. https://doi.org/10.1093/nar/17.21.8413
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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