The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Cis-regulation of the L-type pyruvate kinase gene promoter by glucose, insulin and cyclic AMP
Open accessAbstract
The glucose/insulin response element of the L-pyruvate kinase gene is a perfect palindrome located from nt -168 to -144 with respect to the cap site. This element (L4) is partially homologous to MLTF binding sites. Its full efficiency requires cooperation with a contiguous binding site for HNF4, termed L3 and located from nt -145 to -125. In the presence of the L4 element contiguous to L3, cyclic AMP inhibits activity of the L-PK promoter while in its absence, or when the normal L4-L3 contiguity is modified, cyclic AMP behaves as a transcriptional activator that does not seem to be sequence-specific. Therefore, we propose that the mechanism of inhibition of the L-PK gene by cyclic AMP requires precise interactions between the nucleoprotein complex built up at sites L4 and L3 and other components of the L-PK transcription initiation complex.
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Cites
Sasaki, K., Cripe, T. P., Koch, S. R., Andreone, T. L., Petersen, D. D., Beale, E. G., & Granner, D. K. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42541-5 · Cited by 428
Decaux, J. F., Antoine, B., & Kahn, A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)80103-x · Cited by 172
Self-citationVaulont, S., Munnich, A., Decaux, J. F., & Kahn, A. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)57443-9 · Cited by 147
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Cited by
A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver
Yamashita, H., Takenoshita, M., Sakurai, M., Bruick, R. K., Henzel, W. J., Shillinglaw, W., Arnot, D., & Uyeda, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161284298 · Cited by 682
RNA-Mediated Feedback Control of Transcriptional Condensates
Henninger, J. E., Oksuz, O., Shrinivas, K., Sagi, I., LeRoy, G., Zheng, M. M., Andrews, J. O., Zamudio, A. V., Lazaris, C., Hannett, N. M., et al. (2021) · Cell · doi:10.1016/j.cell.2020.11.030 · Cited by 594
Metadata
- Authors
- Bergot, M.-O., Diaz-Guerra, M.-J. M., Puzenat, N., Raymondjean, M., & Kahn, A.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1992
- Volume
- 20
- Issue
- 8
- Pages
- 1871-1878
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2028102364
- Cited by
- 186
- References
- 3
- FWCI
- 5.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Bergot, M.-O., Diaz-Guerra, M.-J. M., Puzenat, N., Raymondjean, M., & Kahn, A. (1992). Cis-regulation of the L-type pyruvate kinase gene promoter by glucose, insulin and cyclic AMP. Nucleic Acids Research. https://doi.org/10.1093/nar/20.8.1871
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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