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Pfam: multiple sequence alignments and HMM-profiles of protein domains
Open accessAbstract
Pfam contains multiple alignments and hidden Markov model based profiles (HMM-profiles) of complete protein domains. The definition of domain boundaries, family members and alignment is done semi-automatically based on expert knowledge, sequence similarity, other protein family databases and the ability of HMM-profiles to correctly identify and align the members. Release 2.0 of Pfam contains 527 manually verified families which are available for browsing and on-line searching via the World Wide Web in the UK at http://www.sanger.ac.uk/Pfam/ and in the US at http://genome.wustl. edu/Pfam/ Pfam 2.0 matches one or more domains in 50% of Swissprot-34 sequences, and 25% of a large sample of predicted proteins from the Caenorhabditis elegans genome.
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Metadata
- Authors
- Sonnhammer, E.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-01-01
- Volume
- 26
- Issue
- 1
- Pages
- 320-322
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2124871329
- Cited by
- 769
- References
- 0
- FWCI
- 14.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sonnhammer, E. (1998). Pfam: multiple sequence alignments and HMM-profiles of protein domains. Nucleic Acids Research. https://doi.org/10.1093/nar/26.1.320
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