The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation
Open accessAbstract
Rad51 proteins share both structural and functional homologies with the bacterial recombinase RecA. The human Rad51 (HsRad51) is able to catalyse strand exchange between homologous DNA molecules in vitro . However the biological functions of Rad51 in mammals are largely unknown. In order to address this question, we have cloned hamster Rad51 cDNA and overexpressed the corresponding protein in CHO cells. We found that 2-3-fold overexpression of the protein stimulated the homologous recombination between integrated genes by 20-fold indicating that Rad51 is a functional and key enzyme of an intrachromosomal recombination pathway. Cells overexpressing Rad51 were resistant to ionizing radiation when irradiated in late S/G2phase of the cell cycle. This suggests that Rad51 participate in the repair of double-strand breaks most likely by homologous recombination involving sister chromatids formed after the S phase.
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Cites
Sung, P. (1997) · Genes & Development · doi:10.1101/gad.11.9.1111 · Cited by 540
Expression of Human RAD52 Confers Resistance to Ionizing Radiation in Mammalian Cells
Park, M. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.26.15467 · Cited by 109
Cited by
The RAD51 gene family, genetic instability and cancer
Thacker, J. (2005) · Cancer Letters · doi:10.1016/j.canlet.2004.08.018 · Cited by 342
Chopra, N., Tovey, H., Pearson, A., Cutts, R., Toms, C., Proszek, P., Hubank, M., Dowsett, M., Dodson, A., Daley, F., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16142-7 · Cited by 259
RAD51 is involved in repair of damage associated with DNA replication in mammalian cells
Lundin, C., Schultz, N., Arnaudeau, C., Mohindra, A., Hansen, L. T., & Helleday, T. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00313-9 · Cited by 113
Metadata
- Authors
- Vispe, S., Cazaux, C., Lesca, C., & Defais, M.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-06-01
- Volume
- 26
- Issue
- 12
- Pages
- 2859-2864
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2172247857
- Cited by
- 318
- References
- 2
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vispe, S., Cazaux, C., Lesca, C., & Defais, M. (1998). Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation. Nucleic Acids Research. https://doi.org/10.1093/nar/26.12.2859
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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