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Rapid modification of bacterial artificial chromosomes by ET- recombination
Open accessAbstract
We present a method to modify bacterial artificial chromosomes (BACs) resident in their host strain. The method is based on homologous recombination by ET-cloning. We have successfully modified BACs at two distinct loci by recombination with a PCR product containing homology arms of 50 nt. The procedure we describe here is rapid, was found to work with high efficiency and should be applicable to any BAC modification desired.
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Cited by
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Fu, J., Bian, X., Hu, S., Wang, H., Huang, F., Seibert, P. M., Plaza, A., Xia, L., Müller, R., Stewart, A. F., et al. (2012) · Nature Biotechnology · doi:10.1038/nbt.2183 · Cited by 448
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Metadata
- Authors
- Muyrers, J.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-03-15
- Volume
- 27
- Issue
- 6
- Pages
- 1555-1557
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W1993330603
- Cited by
- 532
- References
- 0
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- green
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- Muyrers, J. (1999). Rapid modification of bacterial artificial chromosomes by ET- recombination. Nucleic Acids Research. https://doi.org/10.1093/nar/27.6.1555
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
