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The TIGR Gene Indices: reconstruction and representation of expressed gene sequences
Open accessAbstract
Expressed sequence tags (ESTs) have provided a first glimpse of the collection of transcribed sequences in a variety of organisms. However, a careful analysis of this sequence data can provide significant additional functional, structural and evolutionary information. Our analysis of the public EST sequences, available through the TIGR Gene Indices (TGI; http://www.tigr.org/tdb/tdb.html ), is an attempt to identify the genes represented by that data and to provide additional information regarding those genes. Gene Indices are constructed for selected organisms by first clustering, then assembling EST and annotated gene sequences from GenBank. This process produces a set of unique, high-fidelity virtual transcripts, or tentative consensus (TC) sequences. The TC sequences can be used to provide putative genes with functional annotation, to link the transcripts to mapping and genomic sequence data, and to provide links between orthologous and paralogous genes.
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Cites
CAP3: A DNA Sequence Assembly Program
Huang, X., & Madan, A. (1999) · Genome Research · doi:10.1101/gr.9.9.868 · Cited by 5,261
Cited by
Analysis of the genome sequence of the flowering plant Arabidopsis thaliana
Initiative, T. A. G. (2000) · Nature · doi:10.1038/35048692 · Cited by 9,301
OrthoMCL: Identification of Ortholog Groups for Eukaryotic Genomes
Li, L., Stoeckert, C. J., & Roos, D. S. (2003) · Genome Research · doi:10.1101/gr.1224503 · Cited by 5,707
GMD@CSB.DB: the Golm Metabolome Database
Kopka, J., Schauer, N., Krueger, S., Birkemeyer, C., Usadel, B., Bergmuller, E., Dormann, P., Weckwerth, W., Gibon, Y., Stitt, M., et al. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti236 · Cited by 1,382
The WRKY transcription factor superfamily: its origin in eukaryotes and expansion in plants
Zhang, Y., & Wang, L. (2005) · BMC Evolutionary Biology · doi:10.1186/1471-2148-5-1 · Cited by 834
A Recent Polyploidy Superimposed on Older Large-Scale Duplications in the Arabidopsis Genome
Blanc, G., Hokamp, K., & Wolfe, K. H. (2003) · Genome Research · doi:10.1101/gr.751803 · Cited by 724
Metadata
- Authors
- Quackenbush, J.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-01-01
- Volume
- 28
- Issue
- 1
- Pages
- 141-145
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2164429509
- Cited by
- 342
- References
- 1
- FWCI
- 11.27
- Type
- journal article
- Language
- en
- Open access
- green
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