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A new method for the purification and identification of covalently closed circular DNA molecules
Open accessAbstract
A new technique has been developed for the rapid isolation of covalently closed circular DNA molecules. The procedure is a selective extraction based on differences in the partitioning of covalently closed circular DNA molecules and noncovalently closed species between phenol and water at acid pH and low ionic strength. Under the conditions described, linear as well as nicked circular DNA is extracted into phenol, while covalently closed circular DNA molecules remain in the water phase. The method permits the quantitative isolation of covalently closed circular DNA from either total cellular DNA or partially purified preparations, to a degree of purity comparable with buoyant density procedures.
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Citations
Cited by
[17] A rapid alkaline extraction method for the isolation of plasmid DNA
Birnboim, H. C. (1983) · Methods in Enzymology · doi:10.1016/0076-6879(83)00059-2 · Cited by 964
Iguchi-Ariga, S. M., & Schaffner, W. (1989) · Genes & Development · doi:10.1101/gad.3.5.612 · Cited by 559
Höller, M., Westin, G., Jiricny, J., & Schaffner, W. (1988) · Genes & Development · doi:10.1101/gad.2.9.1127 · Cited by 305
Metadata
- Authors
- Zasloff, M., Ginder, G. D., & Felsenfeld, G.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1978
- Volume
- 5
- Issue
- 4
- Pages
- 1139-1152
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W1989001695
- Cited by
- 205
- References
- 0
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A new method for the purification and identification of covalently closed circular DNA molecules. https://app.cochat.ai/papers/10.1093/nar/5.4.1139
- The paper
- Zasloff, M., Ginder, G. D., & Felsenfeld, G. (1978). A new method for the purification and identification of covalently closed circular DNA molecules. Nucleic Acids Research. https://doi.org/10.1093/nar/5.4.1139
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
