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Release of 7-methylguanine residues whose imidazole rings have been opened from damaged DNA by a DNA glycosylase from Escherichla coli
Open accessAbstract
Double-stranded DNA containing 7-methylguanine residues whose imidazole rings have been opened, i.e. 2,6-diamino-4-hydroxy-5-N-methylformamido-pyrimidine residues, may be prepared by treatment of DNA with dimethyl sulfate followed by prolonged incubation at pH 11.4. These substituted formamidopyrimidine residues are actively removed from DNA by a DNA glycosylase present in E. coli cell extracts. The enz;me shows no apparent cofactor requirement and has a molecular weight of about 30 000. The release of ring-opened 7-methyl-guanine residues is due to a previously unrecognized activity, different from the three known E. coli DNA glycosylases that release uracil, 3-methyladenine, and hypoxanthine from DNA. This enzyme may serve to repair a major secondary alkylation product in DNA. In addition, it may remove nonmethylated purines, whose imidazole rings have been opened, from X-irradiated DNA.
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Cited by
Messenger RNA Turnover in Eukaryotes: Pathways and Enzymes
Meyer, S., Temme, C., & Wahle, E. (2004) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230490513991 · Cited by 342
Boiteux, S., O'Connor, T. R., & Laval, J. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02629.x · Cited by 290
Thomas, D., Scot, A. D., Barbey, R., Padula, M., & Boiteux, S. (1997) · Molecular and General Genetics MGG · doi:10.1007/s004380050405 · Cited by 222
Structures and functions of DNA glycosylases
Sakumi, K., & Sekiguchi, M. (1990) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(90)90003-n · Cited by 106
The role of the mutT gene of Escherichia coli in maintaining replication fidelity
Fowler, R. G., & Schaaper, R. M. (1997) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1997.tb00344.x · Cited by 100
Metadata
- Authors
- Chetsanga, C. J., & Lindahl, T.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1979
- Volume
- 6
- Issue
- 11
- Pages
- 3673-3684
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2037320922
- Cited by
- 265
- References
- 0
- FWCI
- 6.30
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Release of 7-methylguanine residues whose imidazole rings have been opened from damaged DNA by a DNA glycosylase from Escherichla coli. https://app.cochat.ai/papers/10.1093/nar/6.11.3673
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- Chetsanga, C. J., & Lindahl, T. (1979). Release of 7-methylguanine residues whose imidazole rings have been opened from damaged DNA by a DNA glycosylase from Escherichla coli. Nucleic Acids Research. https://doi.org/10.1093/nar/6.11.3673
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