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Rfam: annotating non-coding RNAs in complete genomes

Open access
Griffiths-Jones, S.·2004·Nucleic Acids Research

Abstract

Rfam is a comprehensive collection of non-coding RNA (ncRNA) families, represented by multiple sequence alignments and profile stochastic context-free grammars. Rfam aims to facilitate the identification and classification of new members of known sequence families, and distributes annotation of ncRNAs in over 200 complete genome sequences. The data provide the first glimpses of conservation of multiple ncRNA families across a wide taxonomic range. A small number of large families are essential in all three kingdoms of life, with large numbers of smaller families specific to certain taxa. Recent improvements in the database are discussed, together with challenges for the future. Rfam is available on the Web at http://www.sanger.ac.uk/Software/Rfam/ and http://rfam.wustl.edu/.

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Metadata

Authors
Griffiths-Jones, S.
Venue
Nucleic Acids Research
Published
2004-12-17
Volume
33
Issue
Database issue
Pages
D121-D124
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2042881722
Cited by
1,714
References
4
FWCI
22.52
Type
journal article
Language
en
Open access
green

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Griffiths-Jones, S. (2004). Rfam: annotating non-coding RNAs in complete genomes. Nucleic Acids Research. https://doi.org/10.1093/nar/gki081

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