The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Formation of the G-quadruplex and i-motif structures in retinoblastoma susceptibility genes (Rb)
Open accessAbstract
The formation of G-quadruplex and i-motif structures in the 5' end of the retinoblastoma (Rb) gene was examined using chemical modifications, circular dichroism (CD) and fluorescence spectroscopy. It was found that substitutions of 8-methylguanine at positions that show syn conformations in antiparallel G-quadruplexes stabilize the structure in the G-rich strand. The complementary C-rich 18mer forms an i-motif structure, as suggested by CD spectroscopy. Based on the C to T mutation experiments, C bases participated in the C-C+ base pair of the i-motif structure were determined. Experiments of 2-aminopurine (2-AP) substitution reveal that an increase of fluorescence in the G-quadruplex relative to duplex is attributed to unstacked 2-AP within the loop of G-quadruplex. The fluorescence experiments suggest that formation of the G-quadruplex and i-motif can compete with duplex formation. Furthermore, a polymerase arrest assay indicated that formation the G-quadruplex structure in the Rb gene acts as a barrier in DNA synthesis.
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Cites
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., & Dryja, T. P. (1986) · Nature · doi:10.1038/323643a0 · Cited by 2,948 · cited 1×
“Examination of the Rb gene sequences reveals that regions at the 50 termini are extremely rich in G and C residues (Figure 1) (3,4).”
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Cited by
Highly Efficient G-Quadruplex Recognition by Bisquinolinium Compounds
De Cian, A., DeLemos, E., Mergny, J.-L., Teulade-Fichou, M.-P., & Monchaud, D. (2007) · Journal of the American Chemical Society · doi:10.1021/ja067352b · Cited by 451
Metadata
- Authors
- Xu, Y.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-02-06
- Volume
- 34
- Issue
- 3
- Pages
- 949-954
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2170754011
- Cited by
- 221
- References
- 1
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- gold
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- Xu, Y. (2006). Formation of the G-quadruplex and i-motif structures in retinoblastoma susceptibility genes (Rb). Nucleic Acids Research. https://doi.org/10.1093/nar/gkj485
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