A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

Turlure, F.·2006·Nucleic Acids Research

Cited by (182)

Items 101–182 of 182

  1. Xrp1 genetically interacts with the ALS-associated FUS orthologue caz and mediates its toxicity
    Moushami Mallik, Marica Catinozzi, Clemens B. Hug, Li Zhang, Marina Wagner, Julia Bussmann, Jonas Bittern, Sina Mersmann, Christian Klämbt, Hannes C. A. Drexler et al. · 2018 · The Journal of Cell Biology
  2. Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras
    Lenard S. Vranckx, Jonas Demeulemeester, Zeger Debyser, Rik Gijsbers · 2016 · PLoS ONE
  3. The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights
    S. Hare, Peter Cherepanov · 2009 · Viruses
  4. Chromatin tethering and retroviral integration: Recent discoveries and parallels with DNA viruses
    Anne M. Meehan, Eric M. Poeschla · 2009 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  5. Impact of Chromatin on HIV Replication
    Luis M. Agosto, Matthew Gagné, Andrew J. Henderson · 2015 · Genes
  6. Implication of Serine Residues 271, 273, and 275 in the Human Immunodeficiency Virus Type 1 Cofactor Activity of Lens Epithelium-Derived Growth Factor/p75
    Jose A. Garcia-Rivera, Murilo T. D. Bueno, Elisa Morales, Jeffrey R. Kugelman, Daniel F. Rodríguez, Manuel Llano · 2009 · Journal of Virology
  7. Hepatoma-derived Growth Factor-related Protein-3 Interacts with Microtubules and Promotes Neurite Outgrowth in Mouse Cortical Neurons
    Heba Mahmoud Eltahir, Mekky Mohammed Abouzied, Rainer Gallitzendörfer, Volkmar Gieselmann, Sebastian Franken · 2009 · Journal of Biological Chemistry
  8. The LEM Domain Proteins Emerin and LAP2α Are Dispensable for Human Immunodeficiency Virus Type 1 and Murine Leukemia Virus Infections
    Alok Mulky, Tatiana V. Cohen, С. В. Козлов, Barbara Korbei, Roland Foisner, Colin L. Stewart, Vineet N. KewalRamani · 2008 · Journal of Virology
  9. Lens Epithelium-derived Growth Factor/p75 Qualifies as a Target for HIV Gene Therapy in the NSG Mouse Model
    Sofie Vets, Janine Kimpel, Andreas Volk, Jan De Rijck, Rik Schrijvers, Bert Verbinnen, Wim Maes, Dorotheé von Laer, Zeger Debyser, Rik Gijsbers · 2012 · Molecular Therapy
  10. Characterization of the HIV-1 integrase chromatin- and LEDGF/p75-binding abilities by mutagenic analysis within the catalytic core domain of integrase
    Yingfeng Zheng, Zhujun Ao, Kallesh Danappa Jayappa, Xiaojian Yao · 2010 · Virology Journal
  11. Multivalent interactions essential for lentiviral integrase function
    Allison Ballandras-Colas, Vidya Chivukula, Dominika T. Gruszka, Zelin Shan, Parmit Kumar Singh, Valerie E. Pye, Rebecca K. McLean, Gregory J. Bedwell, Wen Li, Andrea Nans et al. · 2022 · Nature Communications
  12. A Peptide Derived from Lens Epithelium–Derived Growth Factor Stimulates HIV-1 DNA Integration and Facilitates Intasome Structural Studies
    Li, Min, Chen, Xuemin, Wang, Huaibin, Jurado, Kellie A., Engelman, Alan N., Craigie, Robert · 2020 · Journal of Molecular Biology
  13. Furospinosulin‐1, Marine Spongean Furanosesterterpene, Suppresses the Growth of Hypoxia‐Adapted Cancer Cells by Binding to Transcriptional Regulators p54nrb and LEDGF/p75
    Masayoshi Arai, Takashi Kawachi, Naoyuki Kotoku, Chiaki Nakata, Haruhiko Kamada, Shin‐ichi Tsunoda, Yasuo M Tsutsumi, Hiroko Endo, Masahiro Inoue, Hiroki Sato et al. · 2015 · ChemBioChem
  14. Preparation method forEscherichia coli S30 extracts completely dependent upon tRNA addition to catalyze cell-free protein synthesis
    Junho Ahn, Mi-Yeon Hwang, In‐Seok Oh, Kyungmoon Park, Geun‐Hee Hahn, Cha‐Yong Choi, Dong‐Myung Kim · 2006 · Biotechnology and Bioprocess Engineering
  15. Binding to the Other Side: The AT-Hook DNA-Binding Domain Allows Nuclear Factors to Exploit the DNA Minor Groove
    Sabrina Battista, Monica Fedele, Luca Secco, Alberto Maria Davide Ingo, Riccardo Sgarra, Guidalberto Manfioletti · 2024 · International Journal of Molecular Sciences
  16. Retroviral integrase: Structure, mechanism, and inhibition
    Dario Oliveira Passos, Min Li, Robert Craigie, Dmitry Lyumkis · 2021 · The Enzymes
  17. 1,4-Bis(5-(naphthalen-1-yl)thiophen-2-yl)naphthalene, a small molecule, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular Lens epithelium-derived growth factor
    Wan-Gang Gu, Denis Tsz-Ming Ip, Si-jie Liu, Joseph H. Chan, Yan Wang, Xuan Zhang, Yong‐Tang Zheng, David Chi‐Cheong Wan · 2014 · Chemico-Biological Interactions
  18. Site-Specific Integration of Retroviral DNA in Human Cells Using Fusion Proteins Consisting of Human Immunodeficiency Virus Type 1 Integrase and the Designed Polydactyl Zinc-Finger Protein E2C
    K. Su, Dan Wang, Jian Ye, Y. Kim, Samson A. Chow · 2009 · Methods
  19. Blocking Nuclear Import of Pre-Integration Complex: An Emerging Anti-HIV-1 Drug Discovery Paradigm
    Peng Zhan, Xinyong Liu, Erik De Clercq · 2010 · Current Medicinal Chemistry
  20. Identification and functional analysis of NOL7 nuclear and nucleolar localization signals
    Guolin Zhou, Colleen L. Doçi, Mark William Lingen · 2010 · BMC Cell Biology
  21. Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library
    Devan J. Shell, Justin M. Rectenwald, Peter H. Buttery, Rebecca L. Johnson, Caroline A. Foley, Shiva Krishna Reddy Guduru, Mélanie Uguen, Juanita Sanchez Rubiano, Xindi Zhang, Fengling Li et al. · 2022 · SLAS DISCOVERY
  22. Discovery of a Distinct Chemical and Mechanistic Class of Allosteric HIV-1 Integrase Inhibitors with Antiretroviral Activity
    Christine Burlein, Cheng Wang, Min Xu, Triveni Bhatt, Mark W. Stahlhut, Yangsi Ou, Gregory C. Adam, Jeffrey Heath, Daniel J. Klein, John M. Sanders et al. · 2017 · ACS Chemical Biology
  23. Lessons Learned: HIV Points the Way Towards Precision Treatment of Mixed-Lineage Leukemia
    Kateřina Čermáková, Caroline Weydert, Frauke Christ, Jan De Rijck, Zeger Debyser · 2016 · Trends in Pharmacological Sciences
  24. Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD
    Sofie Vets, Jan De Rijck, Christian Brendel, Manuel Grez, Frederic D. Bushman, Zeger Debyser, Rik Gijsbers · 2013 · Molecular Therapy — Nucleic Acids
  25. Identification and characterization of nuclear and nucleolar localization signals in 58-kDa microspherule protein (MSP58)
    Chuan-Pin Yang, Chi-Wu Chiang, Chang-Han Chen, Yi‐Chao Lee, Mei-Hsiang Wu, Yi-Huan Tsou, Yu-San Yang, Wen‐Chang Chang, Ding-Yen Lin · 2015 · Journal of Biomedical Science
  26. TRACE generates fluorescent human reporter cell lines to characterize epigenetic pathways
    Iva A. Tchasovnikarova, Sharon K. Marr, Manashree Damle, Robert E. Kingston · 2021 · Molecular Cell
  27. Dynamics of the Ternary Complex Formed by c-Myc Interactor JPO2, Transcriptional Co-activator LEDGF/p75, and Chromatin
    Jelle Hendrix, Bart van Heertum, Els Vanstreels, Dirk Daelemans, Jan De Rijck · 2014 · Journal of Biological Chemistry
  28. Host Cell Factors and HIV-1 Integration
    Alan Engelman · 2007 · Future HIV Therapy
  29. Repair of Oxidative DNA Base Damage in the Host Genome Influences the HIV Integration Site Sequence Preference
    Geoffrey R. Bennett, Ryan Peters, Xiaohong Wang, Jeungphill Hanne, Robert William Sobol, Ralf A. Bundschuh, Richard A. Fishel, Kristine E. Yoder · 2014 · PLoS ONE
  30. 1,2,3,4‐Tetrahydroisoquinolines as inhibitors of HIV ‐1 integrase and human LEDGF /p75 interaction
    Anu George, Alavala Gopi Krishna Reddy, Gedu Satyanarayana, Nidhanapati Karanam Raghavendra · 2018 · Chemical Biology & Drug Design
  31. Virus–Host Interactions in Retrovirus Integration
    Engelman, Alan N., Maertens, Goedele N. · 2018 · Retrovirus-Cell Interactions
  32. AT-Hook Transcription Factors Show Functions in Liriodendron chinense under Drought Stress and Somatic Embryogenesis
    Yao Tang, Weihuang Wu, Xueyan Zheng, Lu Lu, Xinying Chen, Zhaodong Hao, Siqin Liu, Ying Chen · 2023 · Plants
  33. The Structure-Specific Recognition Protein 1 Associates with Lens Epithelium-Derived Growth Factor Proteins and Modulates HIV-1 Replication
    Angelica P. Lopez, Jeffrey R. Kugelman, Jose A. Garcia-Rivera, Eduardo Urias, Sandra Andrea Salinas, Martín E. Fernández-Zapico, Manuel Llano · 2016 · Journal of Molecular Biology
  34. Targeting Cellular Cofactors in HIV Therapy
    Ralf Dürr, Oliver Till Keppler, Frauke Christ, Emmanuele Crespan, Anna Garbelli, Giovanni Maga, Ursula Dietrich · 2014 · Topics in medicinal chemistry
  35. Therapeutic Targeting of the Menin–KMT2A Interaction
    Pablo R. Freire, Jevon A. Cutler, Scott A. Armstrong · 2024 · Annual Review of Cancer Biology
  36. Molecular Mechanism of LEDGF/p75 Dimerization
    Vanda Lux, Tine Brouns, Kateřina Čermáková, Pavel Srb, Milan Fábry, Marcela Mádlíková, Magda Hořejší, Zdeněk Kukačka, Petr Novák, Michael Kugler et al. · 2020 · Structure
  37. Drosophila P75 safeguards oogenesis by preventing H3K9me2 spreading
    Kun Dou, Yanchao Liu, Yingpei Zhang, Chenhui Wang, Ying Huang, ZZ Zhao Zhang · 2020 · Journal of genetics and genomics/Journal of Genetics and Genomics
  38. Role of LEDGF/p75 (PSIP1) in oncogenesis. Insights in molecular mechanism and therapeutic potential
    Muluembet Z. Akele, Matteo Iervolino, Siska Van Belle, Frauke Christ, Zeger Debyser · 2024 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  39. Identification of the H3K36me3 reader LEDGF/p75 in the pancancer landscape and functional exploration in clear cell renal cell carcinoma
    Yuwei Zhang, Wei Guo, Yangkun Feng, Longfei Yang, Hao Lin, Pengcheng Zhou, Kejie Zhao, Lin Jiang, Bing Yao, Ninghan Feng · 2023 · Computational and Structural Biotechnology Journal
  40. Determinants of Retroviral Integration and Implications for Gene Therapeutic MLV—Based Vectors and for a Cure for HIV-1 Infection
    Eline Pellaers, Anayat Bhat, Frauke Christ, Zeger Debyser · 2022 · Viruses
  41. HIV-1 integrase modulates the interaction of the HIV-1 cellular cofactor LEDGF/p75 with chromatin
    Paulina Astiazaran, Murilo T. D. Bueno, Elisa Morales, Jeffrey R. Kugelman, Jose A. Garcia-Rivera, Manuel Llano · 2011 · Retrovirology
  42. The Involvement of Ubiquitination and SUMOylation in Retroviruses Infection and Latency
    Taizhen Liang, Guojie Li, Yunfei Lu, Meilin Hu, Xiancai Ma · 2023 · Viruses
  43. The Impact of Lens Epithelium-Derived Growth Factor p75 Dimerization on Its Tethering Function
    Tine Brouns, Vanda Lux, Siska Van Belle, Frauke Christ, Václav Veverka, Zeger Debyser · 2024 · Cells
  44. LEDGF/p75 and Transportin-SR2 are Cellular Cofactors of HIV Integrase and Novel Targets for Antiviral Therapy
    Wannes Thys, Katrien Busschots, Melissa McNeely, Arnout R. D. Voet, Frauke Christ, Zeger Debyser · 2009 · HIV Therapy
  45. Cornering HIV: Taking advantage of interactions between selective pressures
    S. Ávila-Ríos, Gustavo Reyes‐Terán, Enrique Espinosa · 2007 · Medical Hypotheses
  46. HIV-1 Integration into Chromatin: New Insights and Future Perspectives
    Paul Lesbats, Marc Lavigne, Vincent Parissi · 2011 · Future Virology
  47. The emerging roles of ubiquitin-like modifications in regulating HIV replication and host defense
    Jinsong Yuan, Huihan Wang, Xiaodong Sun, Chen Huan · 2025 · Frontiers in Cellular and Infection Microbiology
  48. MeCP2 requires interactions with nucleosome linker DNA to read chromatin DNA methylation
    James A. Watson, Beatrice Alexander-Howden, Theo S. Hall, Martin A. Wear, Finlay McGhie, Gillian Clifford, Hannah Wapenaar, Juan Zou, Adrian Peter Bird, Marcus D. Wilson · 2026 · Nature Communications
  49. Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells
    Aviad Levin, Zvi Hayouka, Assaf Friedler, Abraham Loyter · 2010 · Virology Journal
  50. Histone Readers and Their Roles in Cancer
    Hong Wen, Xiaobing Shi · 2023 · Cancer treatment and research
  51. Molecular Crosstalk between HIV-1 Integration and Host Proteins – Implications for Therapeutics
    Youichi Suzuki, Yasutsugu Suzuki, Naoki Yamamoto · 2011 · InTech eBooks
  52. Anti-DFS70 among HIV-positive individuals – A prospective study
    Naim Mahroum, Dolores Perez, Ora Shovman, ‬‬‬‬Abdulla Watad, Boris Gilburd, Howard Amital, Itzchak Levy, Yehuda Shoenfeld · 2018 · Best Practice & Research Clinical Rheumatology
  53. Retroviral Integration Target Site Selection
    Angela Ciuffi, Frederic D. Bushman · 2011 · Wiley eBooks
  54. Disruption of LEDGF/p75-directed integration derepresses antisense transcription of the HIV-1 genome
    Philip R. Tedbury, Darius Mahboubi, Maritza Puray‐Chavez, Raven Shah, Obiaara B. Ukah, Claudia C. Wahoski, Hind J. Fadel, Eric M. Poeschla, Xinlin Gao, William M. McFadden et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  55. Genome-Wide Identification and Expression Analysis of AT-Hook Motif Nuclear Localized Gene Family in Birch
    Bowei Chen, Huaixue Chu, Bin Lv, Yile Guo, Zihui Zhang, Tianxu Zhang, Qingyi Xie, Menghan Hao, Shahid Ali, Wei Jun Zhou et al. · 2025 · Forests
  56. Transgenic expression of the human LEDGF/p75 gene relieves the species barrier against HIV-1 infection in mouse cells
    Takuya Tada, Motohiko Kadoki, Yang Liu, Kenzo Tokunaga, Yoichiro Iwakura · 2013 · Frontiers in Microbiology
  57. Approaches to site-directed DNA integration based on transposases and retroviral integrases
    Ekaterina S. Knyazhanskaya, О. В. Кондрашина, Marina Gottikh · 2011 · Molecular Biology
  58. Biochemical functions of integrase-binding domain of lens epithelium-derived growth factor
    Jin‐Sun Kim, Faysal Bin Hamid, Cha‐Gyun Shin · 2015 · Animal Cells and Systems
  59. Structural basis of thymidine-rich DNA recognition by Drosophila P75 PWWP domain
    Zhaohui Jin, Zhe Meng, Yanchao Liu, Chongyang Li, Xuedi Zhang, Yue Yin, Guanjun Gao, Kun Dou, Ying Huang · 2025 · Communications Biology
  60. Retroviral Vectors for Gene Therapy of Monogenic Diseases
    Kristine E. Yoder, Anthony J. Rabe, Ross C. Larue · 2022 · Springer eBooks
  61. The role of LEDGF in transcription is exploited by HIV-1 to position integration
    Rakesh Pathak, Caroline Esnault, Rajalingam Radhakrishnan, Parmit Kumar Singh, Hongen Zhang, Ryan Dale, Abhishek Anand, Gregory J. Bedwell, Alan Engelman, Ali Rabi et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  62. Association of genetic polymorphisms in select HIV-1 replication cofactors with susceptibility to HIV-1 infection and disease progression.
    Paradise Madlala · 2011 · ResearchSpace (University of KwaZulu-Natal)
  63. Structural aspects of Lentiviral Integrase–LEDGF Interaction
    S. Hare, Alan Engelman, Peter Cherepanov · 2011 · Wiley eBooks
  64. Retroviral Vectors in Gene Therapy: Mechanism of Integration, Successes in Gene Therapy Trials, Emerging Problems and Potential Solutions
    Ahmed F., Johanna A. Smith, Michael P. Lisanti, René Daniel · 2011 · InTech eBooks
  65. TheStressOncoproteinLEDGF/p75InteractswiththeMethyl CpG Binding Protein MeCP2 and Influences Its
    Lai Sum Leoh, Bart van Heertum, Jan De Rijck, Maria Filippova, Leslimar Ríos-Colón, Anamika Basu, Shannalee R. Martinez, Sandy S. Tungteakkhun, Valeri Filippov, Frauke Christ et al. · 2012
  66. SURVEY AND SUMMARY Molecular mechanisms of retroviral integration site selection
    Mamuka Kvaratskhelia, Amit Sharma, Ross C. Larue, Erik Serrao, Alan Engelman · 2014
  67. Mutation of Methionine 178 to Isoleucine of HIV-1 Integrase for analyzing its interaction with LEDGF/p75
    Siddiqui Shazia · 2014 · Research Archive of Indian Institute of Technology Hyderabad (Indian Institute of Technology Hyderabad)
  68. Biochemical and Functional characterization of the LEDGF/p75-MeCP2 Interaction in Tumor Cells
    Lai Sum Leoh · 2011 · The Scholars Repository - LLU (Loma Linda University)
  69. dP75 safeguards oogenesis by preventing H3K9me2 spreading
    Kun Dou, Yanchao Liu, Yingpei Zhang, Chenhui Wang, Ying Huang, ZZ Zhao Zhang · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  70. Proceedings of the Frontiers in Retrovirology Conference 2018
    2018 · Retrovirology
  71. Modulating Target Site Selection During Human Immunodeficiency Virus DNA Integration In Vitro with an Engineered Tethering Factor
    A. Ciuffi, Tracy L. Diamond, Y. Hwang, Heather M. Marshall, F. Bushman · 2006 · Human Gene Therapy
  72. Binding Behavior of Human Hepatoma-Derived Growth Factor on SMYD1
    Jan-Kai Wu, Ying-ying Lee, Hsin Yi Hung, Yuan‐Pin Chang, Ming-Hong Tai, Hsiu‐Fang Fan · 2024 · The Journal of Physical Chemistry B
  73. Identification and evaluation of inhibitors targeting the HIV-1 integrase-LEDGF/p75 interaction
    Angela T. Harrison · 2014 · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)
  74. Characterisation of lens epithelium derived growth factor isoforms in chronic lymphocytic leukemia: Studies and significance
    Jemma Blocksidge · 2014 · University of Liverpool
  75. Relationship between the distribution of LEDGF along genes and positions of HIV-1 DNA integration
    Rakesh Pathak, Caroline Esnault, Rajalingam Radhakrishnan, Parmit Kumar Singh, Hongen Zhang, Ryan Dale, Abhishek Anand, Alapani Mitra, Gregory J. Bedwell, Alan Engelman et al. · 2026 · mBio
  76. Étude de l'émergence in vivo d'un variant de virus de l'immunodéficience humaine de type 1 portant des glycoprotéines d'enveloppe naturellement tronquées dans leur domaine cytoplasmique
    Élodie Beaumont · 2009 · theses.fr (ABES)
  77. Analyse des réponses cellulaires induites par l’intégration d’un ADN étranger au sein du génome
    Virginie Gay · 2010 · theses.fr (ABES)
  78. Élaboration d'Intrabodies ciblant l'organisation conformationnelle du complexe de reverse transcription de VIH-1
    Naïma Abidi-Azzouz · 2013
  79. Identification of specific phylogenetic properties of HIV-1 M and O integrases
    Elenia Toccafondi · 2022 · theses.fr (ABES)
  80. Structural insights into Ty1 yeast retrotransposons DNA integration mechanism at genes transcribed by RNA Polymerase III
    Phong Quoc Nguyen · 2022
  81. PWWP mutants of the transcriptional cofactor JASPer divert promoter and enhancer activities and suppress position effect variegation in Drosophila
    Derek Atkinson, Karolina Barucka, Lisa Jerabek, Francesco Cardamone, Yinxiu Zhan, Lisa Kolodziejczyk, Catherine Regnard, Nicola Iovino, Günter Reuter, Thomas Jenuwein · 2026 · Genes & Development
  82. BindingDB Entry 50003962: Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium.
    BindingDB · 2020 · UC San Diego