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Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA
Open accessAbstract
Here, we report the first example that one enantiomer of a supramolecular cylinder can selectively stabilize human telomeric G-quadruplex DNA. The P-enantiomer of this cylinder has a strong preference for G-quadruplex over duplex DNA and, in the presence of sodium, can convert G-quadruplexes from an antiparallel to a hybrid structure. The compound's chiral selectivity and its ability to discriminate quadruplex DNA have been studied by DNA melting, circular dichroism, gel electrophoresis, fluorescence spectroscopy and S1 nuclease cleavage. The chiral supramolecular complex has both small molecular chemical features and the large size of a zinc-finger-like DNA-binding motif. The complex is also convenient to synthesize and separate enantiomers. These results provide new insights into the development of chiral anticancer agents for targeting G-quadruplex DNA.
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Structure and function of telomeres
Blackburn, E. H. (1991) · Nature · doi:10.1038/350569a0 · Cited by 3,596
Cited by
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Feng, L., Wu, L., & Qu, X. (2013) · Advanced Materials · doi:10.1002/adma.201203229 · Cited by 632
Self-citationChemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA
Xu, Y. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00134a · Cited by 323
Metadata
- Authors
- Yu, H., Wang, X., Fu, M., Ren, J., & Qu, X.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-09-06
- Volume
- 36
- Issue
- 17
- Pages
- 5695-5703
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2071638222
- Cited by
- 182
- References
- 1
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yu, H., Wang, X., Fu, M., Ren, J., & Qu, X. (2008). Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA. Nucleic Acids Research. https://doi.org/10.1093/nar/gkn569
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