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STRING 8--a global view on proteins and their functional interactions in 630 organisms

Open access
Jensen, L. J., Kuhn, M., Stark, M., Chaffron, S., Creevey, C., Muller, J., Doerks, T., Julien, P., Roth, A., Simonovic, M., Bork, P., von Mering, C.·2009·Nucleic Acids Research

Abstract

Functional partnerships between proteins are at the core of complex cellular phenotypes, and the networks formed by interacting proteins provide researchers with crucial scaffolds for modeling, data reduction and annotation. STRING is a database and web resource dedicated to protein-protein interactions, including both physical and functional interactions. It weights and integrates information from numerous sources, including experimental repositories, computational prediction methods and public text collections, thus acting as a meta-database that maps all interaction evidence onto a common set of genomes and proteins. The most important new developments in STRING 8 over previous releases include a URL-based programming interface, which can be used to query STRING from other resources, improved interaction prediction via genomic neighborhood in prokaryotes, and the inclusion of protein structures. Version 8.0 of STRING covers about 2.5 million proteins from 630 organisms, providing the most comprehensive view on protein-protein interactions currently available. STRING can be reached at http://string-db.org/.

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Metadata

Authors
Jensen, L. J., Kuhn, M., Stark, M., Chaffron, S., Creevey, C., Muller, J., Doerks, T., Julien, P., Roth, A., Simonovic, M., Bork, P., & von Mering, C.
Venue
Nucleic Acids Research
Published
2009-01-01
Volume
37
Issue
Database
Pages
D412-D416
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2113613985
Cited by
2,474
References
2
FWCI
73.21
Type
journal article
Language
en
Open access
gold

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Jensen, L. J., Kuhn, M., Stark, M., Chaffron, S., Creevey, C., Muller, J., Doerks, T., Julien, P., Roth, A., Simonovic, M., Bork, P., & von Mering, C. (2009). STRING 8--a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Research. https://doi.org/10.1093/nar/gkn760

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