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Cited by 919

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Rfam: updates to the RNA families database

Open access
Gardner, P. P., Daub, J., Tate, J. G., Nawrocki, E. P., Kolbe, D. L., Lindgreen, S., Wilkinson, A. C., Finn, R. D., Griffiths-Jones, S., Eddy, S. R., Bateman, A.·2009·Nucleic Acids Research

Abstract

Rfam is a collection of RNA sequence families, represented by multiple sequence alignments and covariance models (CMs). The primary aim of Rfam is to annotate new members of known RNA families on nucleotide sequences, particularly complete genomes, using sensitive BLAST filters in combination with CMs. A minority of families with a very broad taxonomic range (e.g. tRNA and rRNA) provide the majority of the sequence annotations, whilst the majority of Rfam families (e.g. snoRNAs and miRNAs) have a limited taxonomic range and provide a limited number of annotations. Recent improvements to the website, methodologies and data used by Rfam are discussed. Rfam is freely available on the Web at http://rfam.sanger.ac.uk/and http://rfam.janelia.org/.

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Metadata

Authors
Gardner, P. P., Daub, J., Tate, J. G., Nawrocki, E. P., Kolbe, D. L., Lindgreen, S., Wilkinson, A. C., Finn, R. D., Griffiths-Jones, S., Eddy, S. R., & Bateman, A.
Venue
Nucleic Acids Research
Published
2009-01-01
Volume
37
Issue
Database
Pages
D136-D140
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W1976021976
Cited by
919
References
2
FWCI
32.63
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Rfam: updates to the RNA families database. https://app.cochat.ai/papers/10.1093/nar/gkn766
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Gardner, P. P., Daub, J., Tate, J. G., Nawrocki, E. P., Kolbe, D. L., Lindgreen, S., Wilkinson, A. C., Finn, R. D., Griffiths-Jones, S., Eddy, S. R., & Bateman, A. (2009). Rfam: updates to the RNA families database. Nucleic Acids Research. https://doi.org/10.1093/nar/gkn766

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