The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells
Open accessAbstract
Lin28 acts as a repressor of microRNA processing and as a post-transcriptional regulatory factor for a subset of mRNAs. Here we report that in human embryonic stem cells Lin28 facilitates the expression of the pivotal pluripotency factor Oct4 at the post-transcriptional level. We provide evidence that Lin28 binds Oct4 mRNA directly through high affinity sites within its coding region and that an interaction between Lin28 and RNA helicase A (RHA) may play a part in the observed regulation. We further demonstrate that decreasing RHA levels impairs Lin28-dependent stimulation of translation in a reporter system. Taken together with previous studies showing that RHA is required for efficient translation of a specific class of mRNAs, these findings suggest a novel mechanism by which Lin28 may affect target mRNA expression and represent the first evidence of post-transcriptional regulation of Oct4 expression by Lin28 in human embryonic stem cells.
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Cites
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310
AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2
Vasudevan, S., & Steitz, J. A. (2007) · Cell · doi:10.1016/j.cell.2007.01.038 · Cited by 656
The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif
Schaeffer, C., Bardoni, B., Mandel, J., Ehresmann, B., Ehresmann, C., & Moine, H. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4803 · Cited by 471
Cited by
The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs
Kallen, A. N., Zhou, X.-B., Xu, J., Qiao, C., Ma, J., Yan, L., Lu, L., Liu, C., Yi, J.-S., Zhang, H., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.027 · Cited by 1,048
Self-citationRole of Oct4 in maintaining and regaining stem cell pluripotency
Shi, G., & Jin, Y. (2010) · Stem Cell Research & Therapy · doi:10.1186/scrt39 · Cited by 294
Metadata
- Authors
- Qiu, C., Ma, Y., Wang, J., Peng, S., & Huang, Y.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-12-04
- Volume
- 38
- Issue
- 4
- Pages
- 1240-1248
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W1973700890
- Cited by
- 218
- References
- 3
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- gold
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- Qiu, C., Ma, Y., Wang, J., Peng, S., & Huang, Y. (2010). Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells. Nucleic Acids Research. https://doi.org/10.1093/nar/gkp1071
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