The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia
Open accessAbstract
The transcription factor Hypoxia-inducible factor 1 (HIF-1) plays a central role in the transcriptional response to oxygen flux. To gain insight into the molecular pathways regulated by HIF-1, it is essential to identify the downstream-target genes. We report here a strategy to identify HIF-1-target genes based on an integrative genomic approach combining computational strategies and experimental validation. To identify HIF-1-target genes microarrays data sets were used to rank genes based on their differential response to hypoxia. The proximal promoters of these genes were then analyzed for the presence of conserved HIF-1-binding sites. Genes were scored and ranked based on their response to hypoxia and their HIF-binding site score. Using this strategy we recovered 41% of the previously confirmed HIF-1-target genes that responded to hypoxia in the microarrays and provide a catalogue of predicted HIF-1 targets. We present experimental validation for ANKRD37 as a novel HIF-1-target gene. Together these analyses demonstrate the potential to recover novel HIF-1-target genes and the discovery of mammalian-regulatory elements operative in the context of microarray data sets.
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Cites
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Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
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Molecular landmarks of tumor hypoxia across cancer types
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CRISPR-Mediated Tagging of Endogenous Proteins with a Luminescent Peptide
Schwinn, M. K., Machleidt, T., Zimmerman, K., Eggers, C. T., Dixon, A. S., Hurst, R., Hall, M. P., Encell, L. P., Binkowski, B. F., & Wood, K. V. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.7b00549 · Cited by 434
Metadata
- Authors
- Benita, Y., Kikuchi, H., Smith, A. D., Zhang, M. Q., Chung, D. C., & Xavier, R. J.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-06-02
- Volume
- 37
- Issue
- 14
- Pages
- 4587-4602
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2098134455
- Cited by
- 478
- References
- 20
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. https://app.cochat.ai/papers/10.1093/nar/gkp425
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- Benita, Y., Kikuchi, H., Smith, A. D., Zhang, M. Q., Chung, D. C., & Xavier, R. J. (2009). An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. Nucleic Acids Research. https://doi.org/10.1093/nar/gkp425
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