The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The MiST2 database: a comprehensive genomics resource on microbial signal transduction
Open accessAbstract
The MiST2 database (http://mistdb.com) identifies and catalogs the repertoire of signal transduction proteins in microbial genomes. Signal transduction systems regulate the majority of cellular activities including the metabolism, development, host-recognition, biofilm production, virulence, and antibiotic resistance of human pathogens. Thus, knowledge of the proteins and interactions that comprise these communication networks is an essential component to furthering biomedical discovery. These are identified by searching protein sequences for specific domain profiles that implicate a protein in signal transduction. Compared to the previous version of the database, MiST2 contains a host of new features and improvements including the following: draft genomes; extracytoplasmic function (ECF) sigma factor protein identification; enhanced classification of signaling proteins; novel, high-quality domain models for identifying histidine kinases and response regulators; neighboring two-component genes; gene cart; better search capabilities; enhanced taxonomy browser; advanced genome browser; and a modern, biologist-friendly web interface. MiST2 currently contains 966 complete and 157 draft bacterial and archaeal genomes, which collectively contain more than 245 000 signal transduction proteins. The majority (66%) of these are one-component systems, followed by two-component proteins (26%), chemotaxis (6%), and finally ECF factors (2%).
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Cites
UniRef: comprehensive and non-redundant UniProt reference clusters
Suzek, B. E., Huang, H., McGarvey, P., Mazumder, R., & Wu, C. H. (2007) · Bioinformatics · doi:10.1093/bioinformatics/btm098 · Cited by 1,613
Cited by
Morcos, F., Pagnani, A., Lunt, B., Bertolino, A., Marks, D. S., Sander, C., Zecchina, R., Onuchic, J. N., Hwa, T., & Weigt, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111471108 · Cited by 1,434
Evolution of Two-Component Signal Transduction Systems
Capra, E. J., & Laub, M. T. (2012) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092611-150039 · Cited by 705
Molecular Mechanisms of Two-Component Signal Transduction
Zschiedrich, C. P., Keidel, V., & Szurmant, H. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.08.003 · Cited by 540
Dintner, S., Staroń, A., Berchtold, E., Petri, T., Mascher, T., & Gebhard, S. (2011) · Journal of Bacteriology · doi:10.1128/jb.05175-11 · Cited by 156
Genomic reconstruction of the transcriptional regulatory network in Bacillus subtilis.
Leyn, S. A., Kazanov, M. D., Sernova, N. V., Ermakova, E. O., Novichkov, P. S., & Rodionov, D. A. (2013) · Journal of Bacteriology · doi:10.1128/jb.00140-13 · Cited by 58
Metadata
- Authors
- Ulrich, L. E., & Zhulin, I. B.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-11-07
- Volume
- 38
- Issue
- suppl_1
- Pages
- D401-D407
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2120423879
- Cited by
- 262
- References
- 1
- FWCI
- 8.20
- Type
- journal article
- Language
- en
- Open access
- gold
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