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VFDB 2012 update: toward the genetic diversity and molecular evolution of bacterial virulence factors

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Chen, L., Xiong, Z., Sun, L., Yang, J., Jin, Q.·2012·Nucleic Acids Research

Abstract

The virulence factor database (VFDB, http://www.mgc.ac.cn/VFs/) has served as a comprehensive repository of bacterial virulence factors (VFs) for >7 years. Bacterial virulence is an exciting and dynamic field, due to the availability of complete sequences of bacterial genomes and increasing sophisticated technologies for manipulating bacteria and bacterial genomes. The intricacy of virulence mechanisms offers a challenge, and there exists a clear need to decipher the 'language' used by VFs more effectively. In this article, we present the recent major updates of VFDB in an attempt to summarize some of the most important virulence mechanisms by comparing different compositions and organizations of VFs from various bacterial pathogens, identifying core components and phylogenetic clades and shedding new light on the forces that shape the evolutionary history of bacterial pathogenesis. In addition, the 2012 release of VFDB provides an improved user interface.

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Metadata

Authors
Chen, L., Xiong, Z., Sun, L., Yang, J., & Jin, Q.
Venue
Nucleic Acids Research
Published
2011-11-08
Volume
40
Issue
D1
Pages
D641-D645
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2072967720
Cited by
541
References
1
FWCI
13.81
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: VFDB 2012 update: toward the genetic diversity and molecular evolution of bacterial virulence factors. https://app.cochat.ai/papers/10.1093/nar/gkr989
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Chen, L., Xiong, Z., Sun, L., Yang, J., & Jin, Q. (2012). VFDB 2012 update: toward the genetic diversity and molecular evolution of bacterial virulence factors. Nucleic Acids Research. https://doi.org/10.1093/nar/gkr989

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