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The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

SIFT web server: predicting effects of amino acid substitutions on proteins

Open access
Sim, Ngak-Leng, Kumar, Prateek, Hu, Jing, Henikoff, Steven, Schneider, Georg, Ng, Pauline C.·2012·Nucleic Acids Research

Abstract

The Sorting Intolerant from Tolerant (SIFT) algorithm predicts the effect of coding variants on protein function. It was first introduced in 2001, with a corresponding website that provides users with predictions on their variants. Since its release, SIFT has become one of the standard tools for characterizing missense variation. We have updated SIFT's genome-wide prediction tool since our last publication in 2009, and added new features to the insertion/deletion (indel) tool. We also show accuracy metrics on independent data sets. The original developers have hosted the SIFT web server at FHCRC, JCVI and the web server is currently located at BII. The URL is http://sift-dna.org (24 May 2012, date last accessed).

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Metadata

Authors
Sim, N.-L., Kumar, P., Hu, J., Henikoff, S., Schneider, G., & Ng, P. C.
Venue
Nucleic Acids Research
Published
2012-06-09
Volume
40
Issue
W1
Pages
W452-W457
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2137886330
Cited by
2,411
References
8
FWCI
32.06
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: SIFT web server: predicting effects of amino acid substitutions on proteins. https://app.cochat.ai/papers/10.1093/nar/gks539
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Sim, N.-L., Kumar, P., Hu, J., Henikoff, S., Schneider, G., & Ng, P. C. (2012). SIFT web server: predicting effects of amino acid substitutions on proteins. Nucleic Acids Research. https://doi.org/10.1093/nar/gks539

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