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The immune epitope database (IEDB) 3.0
Open accessAbstract
The IEDB, www.iedb.org, contains information on immune epitopes--the molecular targets of adaptive immune responses--curated from the published literature and submitted by National Institutes of Health funded epitope discovery efforts. From 2004 to 2012 the IEDB curation of journal articles published since 1960 has caught up to the present day, with >95% of relevant published literature manually curated amounting to more than 15,000 journal articles and more than 704,000 experiments to date. The revised curation target since 2012 has been to make recent research findings quickly available in the IEDB and thereby ensure that it continues to be an up-to-date resource. Having gathered a comprehensive dataset in the IEDB, a complete redesign of the query and reporting interface has been performed in the IEDB 3.0 release to improve how end users can access this information in an intuitive and biologically accurate manner. We here present this most recent release of the IEDB and describe the user testing procedures as well as the use of external ontologies that have enabled it.
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Cited by
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SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition
Nelde, A., Bilich, T., Heitmann, J. S., Maringer, Y., Salih, H. R., Roerden, M., Lübke, M., Bauer, J., Rieth, J., Wacker, M., et al. (2021) · Nature Immunology · doi:10.1038/s41590-020-00808-x · Cited by 582
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Tickotsky, N., Sagiv, T., Prilusky, J., Shifrut, E., & Friedman, N. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btx286 · Cited by 555
Sarkizova, S., Klaeger, S., Le, P. M., Li, L. W., Oliveira, G., Keshishian, H., Hartigan, C. R., Zhang, W., Braun, D. A., Ligon, K. L., et al. (2020) · Nature Biotechnology · doi:10.1038/s41587-019-0322-9 · Cited by 499
Metadata
- Authors
- Vita, R., Overton, J. A., Greenbaum, J. A., Ponomarenko, J., Clark, J. D., Cantrell, J. R., Wheeler, D. K., Gabbard, J. L., Hix, D., Sette, A., & Peters, B.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-10-09
- Volume
- 43
- Issue
- D1
- Pages
- D405-D412
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2053707749
- Cited by
- 1,052
- References
- 0
- FWCI
- 29.20
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: The immune epitope database (IEDB) 3.0. https://app.cochat.ai/papers/10.1093/nar/gku938
- The paper
- Vita, R., Overton, J. A., Greenbaum, J. A., Ponomarenko, J., Clark, J. D., Cantrell, J. R., Wheeler, D. K., Gabbard, J. L., Hix, D., Sette, A., & Peters, B. (2015). The immune epitope database (IEDB) 3.0. Nucleic Acids Research. https://doi.org/10.1093/nar/gku938
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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