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Cited by 2,676

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MetaboAnalyst 3.0—making metabolomics more meaningful

Open access
Xia, Jianguo, Sinelnikov, Igor V., Han, Beomsoo, Wishart, David S.·2015·Nucleic Acids Research

Abstract

MetaboAnalyst (www.metaboanalyst.ca) is a web server designed to permit comprehensive metabolomic data analysis, visualization and interpretation. It supports a wide range of complex statistical calculations and high quality graphical rendering functions that require significant computational resources. First introduced in 2009, MetaboAnalyst has experienced more than a 50X growth in user traffic (>50 000 jobs processed each month). In order to keep up with the rapidly increasing computational demands and a growing number of requests to support translational and systems biology applications, we performed a substantial rewrite and major feature upgrade of the server. The result is MetaboAnalyst 3.0. By completely re-implementing the MetaboAnalyst suite using the latest web framework technologies, we have been able substantially improve its performance, capacity and user interactivity. Three new modules have also been added including: (i) a module for biomarker analysis based on the calculation of receiver operating characteristic curves; (ii) a module for sample size estimation and power analysis for improved planning of metabolomics studies and (iii) a module to support integrative pathway analysis for both genes and metabolites. In addition, popular features found in existing modules have been significantly enhanced by upgrading the graphical output, expanding the compound libraries and by adding support for more diverse organisms.

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Metadata

Authors
Xia, J., Sinelnikov, I. V., Han, B., & Wishart, D. S.
Venue
Nucleic Acids Research
Published
2015-04-20
Volume
43
Issue
W1
Pages
W251-W257
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W1976327004
Cited by
2,676
References
1
FWCI
170.60
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: MetaboAnalyst 3.0—making metabolomics more meaningful. https://app.cochat.ai/papers/10.1093/nar/gkv380
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Xia, J., Sinelnikov, I. V., Han, B., & Wishart, D. S. (2015). MetaboAnalyst 3.0—making metabolomics more meaningful. Nucleic Acids Research. https://doi.org/10.1093/nar/gkv380

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