Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 2,855

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

The Reactome Pathway Knowledgebase

Open access
Fabregat, Antonio, Jupe, Steven, Matthews, Lisa, Sidiropoulos, Konstantinos, Gillespie, Marc, Garapati, Phani, Haw, Robin, Jassal, Bijay, Korninger, Florian, May, Bruce, Milacic, Marija, Roca, Corina Duenas, Rothfels, Karen, Sevilla, Cristoffer, Shamovsky, Veronica, Shorser, Solomon, Varusai, Thawfeek, Viteri, Guilherme, Weiser, Joel, Wu, Guanming, Stein, Lincoln, Hermjakob, Henning, D’Eustachio, Peter·2018·Nucleic Acids Research

Abstract

The Reactome Knowledgebase (https://reactome.org) provides molecular details of signal transduction, transport, DNA replication, metabolism, and other cellular processes as an ordered network of molecular transformations-an extended version of a classic metabolic map, in a single consistent data model. Reactome functions both as an archive of biological processes and as a tool for discovering unexpected functional relationships in data such as gene expression profiles or somatic mutation catalogues from tumor cells. To support the continued brisk growth in the size and complexity of Reactome, we have implemented a graph database, improved performance of data analysis tools, and designed new data structures and strategies to boost diagram viewer performance. To make our website more accessible to human users, we have improved pathway display and navigation by implementing interactive Enhanced High Level Diagrams (EHLDs) with an associated icon library, and subpathway highlighting and zooming, in a simplified and reorganized web site with adaptive design. To encourage re-use of our content, we have enabled export of pathway diagrams as 'PowerPoint' files.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/nar/gkx1132

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 3 references

Research works printed but not linked: 8

  1. 2017, KEGG: new perspectives on genomes, pathways, diseases and drugs, Nucleic Acids Res., 45, D353, 10.1093/nar/gkw1092 · DOI · Paper page
  2. 2017, PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements, Nucleic Acids Res., 45, D183, 10.1093/nar/gkw1138 · DOI · Paper page
  3. 2016, The Reactome Pathway Knowledgebase, Nucleic Acids Res., 44, D481, 10.1093/nar/gkv1351 · DOI · Paper page
  4. 2015, Disease Ontology 2015 update: an expanded and updated database of human diseases for linking biomedical knowledge through disease data, Nucleic Acids Res., 43, D1071, 10.1093/nar/gku1011 · DOI · Paper page
  5. 2009, Survey and summary. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists, Nucleic Acids Res., 37, 1, 10.1093/nar/gkn923 · DOI · Paper page
  6. 2003, Global functional profiling of gene expression, Genomics, 81, 98
  7. 2016, Reactome pathway analysis: a high-performance in-memory approach, BMC Bioinformatics, 18, 142
  8. 2017, Reactome enhanced pathway visualization, Bioinformatics

Cited by

See all 2,855

Metadata

Authors
Fabregat, A., Jupe, S., Matthews, L., Sidiropoulos, K., Gillespie, M., Garapati, P., Haw, R., Jassal, B., Korninger, F., May, B., Milacic, M., Roca, C. D., Rothfels, K., Sevilla, C., Shamovsky, V., Shorser, S., Varusai, T., Viteri, G., Weiser, J., Wu, G., Stein, L., Hermjakob, H., & D’Eustachio, P.
Venue
Nucleic Acids Research
Published
2017-11-14
Volume
46
Issue
D1
Pages
D649-D655
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W4233698560
Cited by
2,855
References
3
FWCI
115.11
Type
journal article
Language
en
Open access
gold

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: The Reactome Pathway Knowledgebase. https://app.cochat.ai/papers/10.1093/nar/gkx1132
The paper
Fabregat, A., Jupe, S., Matthews, L., Sidiropoulos, K., Gillespie, M., Garapati, P., Haw, R., Jassal, B., Korninger, F., May, B., Milacic, M., Roca, C. D., Rothfels, K., Sevilla, C., Shamovsky, V., Shorser, S., Varusai, T., Viteri, G., Weiser, J., . . . D’Eustachio, P. (2018). The Reactome Pathway Knowledgebase. Nucleic Acids Research. https://doi.org/10.1093/nar/gkx1132

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.