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UniProt: a worldwide hub of protein knowledge
Open accessAbstract
The UniProt Knowledgebase is a collection of sequences and annotations for over 120 million proteins across all branches of life. Detailed annotations extracted from the literature by expert curators have been collected for over half a million of these proteins. These annotations are supplemented by annotations provided by rule based automated systems, and those imported from other resources. In this article we describe significant updates that we have made over the last 2 years to the resource. We have greatly expanded the number of Reference Proteomes that we provide and in particular we have focussed on improving the number of viral Reference Proteomes. The UniProt website has been augmented with new data visualizations for the subcellular localization of proteins as well as their structure and interactions. UniProt resources are available under a CC-BY (4.0) license via the web at https://www.uniprot.org/.
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“The newly added data includes mouse and rat proteins from UniProt (5), with their associated phenotype data extracted from the International Mouse Phenotyping Consortium (6) and the Rat Genome Database (7), respectively.”
From TCRD and pharos 2021: mining the human proteome for disease biology (2021) · cites this paper as [5]
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Metadata
- Authors
- The UniProt Consortium
- Affiliations
- SIB Swiss Institute of Bioinformatics (CH)
- Corresponding author
- The UniProt Consortium
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-11-05
- Volume
- 47
- Issue
- D1
- Pages
- D506-D515
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- PMC
- PMC6323992
- OpenAlex
- W3136918052
- Cited by
- 7,698
- References
- 33
- Citations by year
- 2026: 358 · 2025: 676 · 2024: 807 · 2023: 831 · 2022: 1111 · 2021: 1825 · 2020: 1620 · 2019: 449 · 2018: 5
- FWCI
- 351.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nucleic Acids Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (U24HG007822)
- National Human Genome Research Institute (U41HG007822, U41HG002273)
- National Institute of General Medical Sciences (R01GM080646, P20GM103446, U01GM120953)
- Biotechnology and Biological Sciences Research Council (BB/M011674/1)
- British Heart Foundation (RG/13/5/30112)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Health Sciences › Medicine › Health Informatics › Biomedical Text Mining and Ontologies
- Keywords
- protein sequence databases, protein annotation, reference proteomes, viral proteome, subcellular localization, protein structure, protein-protein interaction, data visualization, expert curation, rule-based annotation
- MeSH terms
- Sequence Analysis, Protein, Proteome, Databases, Protein, Knowledge Bases, Molecular Sequence Annotation, Data Curation
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