The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Real-time monitoring of DNA G-quadruplexes in living cells with a small-molecule fluorescent probe
Open accessAbstract
G-quadruplex DNA has been viewed as a prospective anti-cancer target owing to its potential biological relevance. Real-time monitoring of DNA G-quadruplex structures in living cells can provide valuable insights into the relationship between G-quadruplex formation and its cellular consequences. However, the probes capable of detecting DNA G-quadruplexes in living cells are still very limited. Herein, we reported a new fluorescent probe, IMT, for real-time visualization of DNA G-quadruplex structures in living cells. Using IMT as a fluorescent indicator, the quantity changes of DNA G-quadruplex at different points in time during continuous cellular progression responding to Aphidicolin and Hydroxyurea treatment have been directly visualized. Our data demonstrate that IMT will be a valuable tool for exploring DNA G-quadruplexes in live cells. Further application of IMT in fluorescence imaging may reveal more information on the roles of DNA G-quadruplexes in biological systems.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Small-molecule–induced DNA damage identifies alternative DNA structures in human genes
Rodriguez, R., Miller, K. M., Forment, J. V., Bradshaw, C. R., Nikan, M., Britton, S., Oelschlaegel, T., Xhemalce, B., Balasubramanian, S., & Jackson, S. P. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.780 · Cited by 741
Paeschke, K., Capra, J. A., & Zakian, V. A. (2011) · Cell · doi:10.1016/j.cell.2011.04.015 · Cited by 566 · cited 1×
“G-quadruplex DNA, a non-canonical secondary nucleic acid structure formed by guanine-rich genomic sequences (1,2), has been viewed as an emerging therapeutic target in oncology due to its potential roles in oncogene transcriptional regulation (3), DNA replication (4) and telomere stability (5,6).”
Background
Cited by
The Structure and Function of DNA G-Quadruplexes
Spiegel, J., Adhikari, S., & Balasubramanian, S. (2020) · Trends in Chemistry · doi:10.1016/j.trechm.2019.07.002 · Cited by 920
Fluorescent probes for the detection of disease-associated biomarkers
Dou, W.-T., Han, H.-H., Sedgwick, A. C., Zhu, G.-B., Zang, Y., Yang, X.-R., Yoon, J., James, T. D., Li, J., & He, X.-P. (2022) · Science Bulletin · doi:10.1016/j.scib.2022.01.014 · Cited by 266
Advances and challenges in identifying and characterizing G-quadruplex–protein interactions
Dai, Y., Teng, X., Zhang, Q., Hou, H., & Li, J. (2023) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2023.06.007 · Cited by 46
Metadata
- Authors
- Zhang, S., Sun, H., Wang, L., Liu, Y., Chen, H., Li, Q., Guan, A., Liu, M., & Tang, Y.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-07-31
- Volume
- 46
- Issue
- 15
- Pages
- 7522-7532
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2887499420
- Cited by
- 159
- References
- 2
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Real-time monitoring of DNA G-quadruplexes in living cells with a small-molecule fluorescent probe. https://app.cochat.ai/papers/10.1093/nar/gky665
- The paper
- Zhang, S., Sun, H., Wang, L., Liu, Y., Chen, H., Li, Q., Guan, A., Liu, M., & Tang, Y. (2018). Real-time monitoring of DNA G-quadruplexes in living cells with a small-molecule fluorescent probe. Nucleic Acids Research. https://doi.org/10.1093/nar/gky665
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
