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MitoZ: a toolkit for animal mitochondrial genome assembly, annotation and visualization

Open access
Meng, Guanliang, Li, Yiyuan, Yang, Chentao, Liu, Shanlin·2019·Nucleic Acids Research

Abstract

Mitochondrial genome (mitogenome) plays important roles in evolutionary and ecological studies. It becomes routine to utilize multiple genes on mitogenome or the entire mitogenomes to investigate phylogeny and biodiversity of focal groups with the onset of High Throughput Sequencing (HTS) technologies. We developed a mitogenome toolkit MitoZ, consisting of independent modules of de novo assembly, findMitoScaf (find Mitochondrial Scaffolds), annotation and visualization, that can generate mitogenome assembly together with annotation and visualization results from HTS raw reads. We evaluated its performance using a total of 50 samples of which mitogenomes are publicly available. The results showed that MitoZ can recover more full-length mitogenomes with higher accuracy compared to the other available mitogenome assemblers. Overall, MitoZ provides a one-click solution to construct the annotated mitogenome from HTS raw data and will facilitate large scale ecological and evolutionary studies. MitoZ is free open source software distributed under GPLv3 license and available at https://github.com/linzhi2013/MitoZ.

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Metadata

Authors
Meng, G., Li, Y., Yang, C., & Liu, S.
Venue
Nucleic Acids Research
Published
2019-03-13
Volume
47
Issue
11
Pages
e63-e63
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2950509696
Cited by
1,155
References
53
FWCI
27.57
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: MitoZ: a toolkit for animal mitochondrial genome assembly, annotation and visualization. https://app.cochat.ai/papers/10.1093/nar/gkz173
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Meng, G., Li, Y., Yang, C., & Liu, S. (2019). MitoZ: a toolkit for animal mitochondrial genome assembly, annotation and visualization. Nucleic Acids Research. https://doi.org/10.1093/nar/gkz173

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