The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
The malnutrition, inflammation, and atherosclerosis (MIA) syndrome - the heart of the matter
Abstract
The majority of patients starting dialysis already have signs of advanced atherosclerosis, and the risk factors for cardiovascular morbidity and mortality seen in patients with end-stage renal disease (ESRD) develop with the disease progression. Therefore, the predialysis period is the ideal time to start therapeutic interventions. Traditional risk factors alone may not adequately predict cardiovascular disease (CVD) outcome in patients with ESRD. Inflammation has been identified as playing a key role in atherosclerotic CVD. Pro-inflammatory cytokines are pivotal to the inflammation that is associated with malnutrition and atherosclerosis in ESRD. Malnutrition may worsen patient outcome by aggravating existing inflammation and heart failure, accelerating atherosclerosis and increasing susceptibility to infection. Atherosclerosis is itself a major risk factor for CVD mortality. Moreover, inflammation is associated with congestive heart failure. Strong associations between malnutrition, inflammation and atherosclerosis in this patient population suggest the presence of a syndrome we have called malnutrition, inflammation, and atherosclerosis (MIA), which is associated with an exceptionally high mortality rate.
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Citations
Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Clinical epidemiology of cardiovascular disease in chronic renal disease
Foley, R., Parfrey, P., & Sarnak, M. (1998) · American Journal of Kidney Diseases · doi:10.1053/ajkd.1998.v32.pm9820470 · Cited by 3,958
Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure
Levine, B., Kalman, J., Mayer, L., Fillit, H. M., & Packer, M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007263230405 · Cited by 2,582 · cited 1×
“In the general population, CHF is associated with both malnutrition (cardiac cachexia) and increased levels of pro-inflammatory cytokines [30].”
BackgroundRidker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000) · Circulation · doi:10.1161/01.cir.101.15.1767 · Cited by 2,429
Block, G., Hulbert-Shearon, T., Levin, N., & Port, F. (1998) · American Journal of Kidney Diseases · doi:10.1053/ajkd.1998.v31.pm9531176 · Cited by 2,354
Lowrie, E. G., & Lew, N. L. (1990) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(12)70364-5 · Cited by 1,976
Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure
Stenvinkel, P., Heimbürger, O., Paultre, F., Diczfalusy, U., Wang, T., Berglund, L., & Jogestrand, T. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00422.x · Cited by 1,778
Self-citationInflammation enhances cardiovascular risk and mortality in hemodialysis patients
Zimmermann, J., Herrlinger, S., Pruy, A., Metzger, T., & Wanner, C. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00273.x · Cited by 1,531
Endotoxin and immune activation in chronic heart failure: a prospective cohort study
Niebauer, J., Volk, H.-D., Kemp, M., Dominguez, M., Schumann, R. R., Rauchhaus, M., Poole-Wilson, P. A., Coats, A. J., & Anker, S. D. (1999) · The Lancet · doi:10.1016/s0140-6736(98)09286-1 · Cited by 877
Stenvinkel, P., Heimbürger, O., Lindholm, B., Kaysen, G. A., & Bergström, J. (2000) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/15.7.953 · Cited by 811
Self-citation
Cited by
Hemodialysis-Induced Cardiac Injury: Determinants and Associated Outcomes
Burton, J. O., Jefferies, H. J., Selby, N. M., & McIntyre, C. W. (2009) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03900808 · Cited by 686
Heart failure and kidney dysfunction: epidemiology, mechanisms and management
Schefold, J. C., Filippatos, G., Hasenfuss, G., Anker, S. D., & von Haehling, S. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.113 · Cited by 671
Metadata
- Authors
- Pecoits-Filho, R., Lindholm, B., & Stenvinkel, P.
- Venue
- Nephrology Dialysis Transplantation
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-11-01
- Volume
- 17
- Issue
- suppl 11
- Pages
- 28-31
- ISSN
- 0931-0509 (ISSN-L)
- 1460-2385
- OpenAlex
- W2165222873
- Cited by
- 429
- References
- 30
- FWCI
- 10.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pecoits-Filho, R., Lindholm, B., & Stenvinkel, P. (2002). The malnutrition, inflammation, and atherosclerosis (MIA) syndrome - the heart of the matter. Nephrology Dialysis Transplantation. https://doi.org/10.1093/ndt/17.suppl_11.28
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
