Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 477

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Serum iPTH, calcium and phosphate, and the risk of mortality in a European haemodialysis population

Open access
Floege, J., Kim, J., Ireland, E., Chazot, C., Drueke, T., de Francisco, A., Kronenberg, F., Marcelli, D., Passlick-Deetjen, J., Schernthaner, G., Fouqueray, B., Wheeler, D. C., on behalf of the ARO Investigators·2011·Nephrology Dialysis Transplantation
DOI 10.1093/ndt/gfq219
Open this paper in CoChat — free account

Abstract

BACKGROUND: A number of US observational studies reported an increased mortality risk with higher intact parathyroid hormone (iPTH), calcium and/or phosphate. The existence of such a link in a European haemodialysis population was explored as part of the Analysing Data, Recognising Excellence and Optimising Outcomes (ARO) Chronic Kidney Disease (CKD) Research Initiative. METHODS: The association between the markers of mineral and bone disease and clinical outcomes was examined in 7970 patients treated in European Fresenius Medical Care facilities over a median of 21 months. Baseline and time-dependent (TD) Cox regression were performed using Kidney Disease Outcomes Quality Initiative (KDOQI) target ranges as reference categories, adjusting for demographics, medical history, dialysis parameters, inflammation, medications and laboratory parameters. Fractional polynomial (FP) models were also used. RESULTS: Hazard ratio (HR) estimates from baseline analysis for iPTH were U-shaped [>600 pg/mL, HR = 2.10, 95% confidence interval (CI) 1.62-2.73; <75 pg/mL, HR = 1.46, 95% CI 1.17-1.83]. TD analysis confirmed the results for iPTH. Baseline analysis showed that calcium >2.75 mmol/L increased risk of death (HR = 1.70, 95% CI 1.19-2.42). TD analysis showed that both low (HR = 1.19, 95% CI 1.04-1.37) and high calcium (HR = 1.74, 95% CI 1.30-2.34) increased risk of death. Baseline analysis for phosphate showed a U-shaped pattern (<1.13 mmol/L, HR = 1.18, 95% CI 1.01-1.37; >1.78 mmol/L, HR = 1.32, 95% CI 1.13-1.55). TD analysis confirmed the results for phosphate <1.13 mmol/L. HR estimates were higher in patients with diabetes versus those without diabetes for baseline analysis only (P-value = 0.014). FP analysis confirmed the results of baseline and TD analyses. CONCLUSION: Patients with iPTH, calcium and phosphate levels within the KDOQI target ranges have the lowest risk of mortality compared with those outside the target ranges.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/ndt/gfq219

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 25 references

Cited by

See all 477

Metadata

Authors
Floege, J., Kim, J., Ireland, E., Chazot, C., Drueke, T., de Francisco, A., Kronenberg, F., Marcelli, D., Passlick-Deetjen, J., Schernthaner, G., Fouqueray, B., Wheeler, D. C., & on behalf of the ARO Investigators
Venue
Nephrology Dialysis Transplantation
Publisher
Oxford University Press (OUP)
Published
2010-04-25
Volume
26
Issue
6
Pages
1948-1955
ISSN
  • 0931-0509 (ISSN-L)
  • 1460-2385
DOI
10.1093/ndt/gfq219
OpenAlex
W2138829372
Cited by
477
References
25
FWCI
18.98
Type
journal article
Language
en
Open access
hybrid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Serum iPTH, calcium and phosphate, and the risk of mortality in a European haemodialysis population. https://app.cochat.ai/papers/10.1093/ndt/gfq219
The paper
Floege, J., Kim, J., Ireland, E., Chazot, C., Drueke, T., de Francisco, A., Kronenberg, F., Marcelli, D., Passlick-Deetjen, J., Schernthaner, G., Fouqueray, B., Wheeler, D. C., & on behalf of the ARO Investigators. (2011). Serum iPTH, calcium and phosphate, and the risk of mortality in a European haemodialysis population. Nephrology Dialysis Transplantation. https://doi.org/10.1093/ndt/gfq219

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.